{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:38:56Z","timestamp":1778657936405,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Correct action upon re\u2010emergence of minimal residual disease in acute myeloid leukaemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>) patients has not yet been established. The applicability of demethylating agents and use of allogeneic stem cell transplantation will be dependent on pre\u2010relapse <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> growth rates. We here delineate molecular growth kinetics of <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> harbouring <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic> partial tandem duplication (<jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content>\u2010<\/jats:italic><jats:styled-content style=\"fixed-case\">PTD<\/jats:styled-content>; 37 cases) compared to those harbouring <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic> translocations (43 cases). The kinetics of <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content>\u2010<\/jats:italic><jats:styled-content style=\"fixed-case\">PTD<\/jats:styled-content> relapses was both significantly slower than those of <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic> translocation positive ones (median doubling time: <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PTD<\/jats:styled-content><\/jats:italic>: 24\u00a0d, <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content>\u2010<\/jats:italic>translocations: 12\u00a0d, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7015, Wilcoxon rank sum test), and displayed greater variation depending on additional mutations. Thus, <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">PTD<\/jats:styled-content>+ cases with additional <jats:italic><jats:styled-content style=\"fixed-case\">RUNX<\/jats:styled-content>1<\/jats:italic> mutations or <jats:italic><jats:styled-content style=\"fixed-case\">FLT<\/jats:styled-content>3<\/jats:italic>\u2010internal tandem duplication relapsed significantly faster than cases without one of those two mutations (Wilcoxon rank sum test, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0\u00b7042). As rapid relapses occurred in all <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic> subgroups, frequent sampling are necessary to obtain acceptable relapse detection rates and times from molecular relapse to haematological relapse (blood sampling every second month: <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">PTD<\/jats:styled-content>: 75%\/50\u00a0d; <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic> translocations: 85%\/25\u00a0d). In conclusion, in this cohort relapse kinetics is heavily dependent on <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> subtype as well as additional genetic aberrations, with possibly great consequences for the rational choice of pre\u2010emptive therapies.<\/jats:p>","DOI":"10.1111\/bjh.12792","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T18:21:07Z","timestamp":1393266067000},"page":"618-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Relapse kinetics in acute myeloid leukaemias with <i><scp>MLL<\/scp><\/i> translocations or partial tandem duplications within the <i><scp>MLL<\/scp><\/i> gene"],"prefix":"10.1111","volume":"165","author":[{"given":"Hans B.","family":"Ommen","sequence":"first","affiliation":[{"name":"Department of Haematology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hokland","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Haferlach","sequence":"additional","affiliation":[{"name":"MLL Munich Leukaemia Laboratory Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotte","family":"Abildgaard","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Alpermann","sequence":"additional","affiliation":[{"name":"MLL Munich Leukaemia Laboratory Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Haferlach","sequence":"additional","affiliation":[{"name":"MLL Munich Leukaemia Laboratory Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Kern","sequence":"additional","affiliation":[{"name":"MLL Munich Leukaemia Laboratory Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Schnittger","sequence":"additional","affiliation":[{"name":"MLL Munich Leukaemia Laboratory Munich 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