{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:33Z","timestamp":1787013933475,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Stroke is a traumatic complication in sickle cell anaemia (\n                    <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>\n                    ) that is associated with significant morbidity and a risk of recurrent overt stroke of 2\u00b72\u20136\u00b74 events per 100 patient\u2010years. A retrospective study was performed on all paediatric\n                    <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>\n                    patients diagnosed with a history of overt stroke between 1997 and 2010. A total of 31 children with\n                    <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>\n                    had new onset overt stroke. The mean age of the active patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a027) was 17\u00b79\u00a0years (range 6\u00b78\u201327\u00b76\u00a0years) with a total period of observation of 305 patient\u2010years. Twenty\u2010two of 27 (81%) were receiving long term red blood cell transfusions and 16 (59%) were taking the anti\u2010platelet agent, aspirin, since diagnosis of the stroke. Two of 27 (7%) patients had a second overt stroke with an overall risk of recurrent stroke of 0\u00b766\/100 patient\u2010years (one stroke was ischaemic and the other haemorrhagic). In patients taking aspirin with 180 patient\u2010years of follow up, the recurrence rate of haemorrhagic stroke was 0\u00b758\/100 patient\u2010years. We have an excellent outcome for overt stroke in paediatric\n                    <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>\n                    patients with a low rate of recurrent stroke. Further studies are needed to determine the risk\u2010benefit ratio of aspirin therapy in the prevention of recurrent stroke in paediatric\n                    <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/bjh.12795","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T02:39:14Z","timestamp":1393382354000},"page":"707-713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Outcome of overt stroke in sickle cell anaemia, a single institution's experience"],"prefix":"10.1111","volume":"165","author":[{"given":"Suvankar","family":"Majumdar","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Mississippi Medical Center Jackson MS 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