{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T20:44:48Z","timestamp":1792356288952,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Transplantation of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell depleted allografts from haploidentical family donors was evaluated within a prospective phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> trial in children with acute lymphoblastic leukaemia, acute myeloid leukaemia and advanced myelodysplastic syndrome (<jats:italic>n<\/jats:italic>\u00a0=\u00a046). 20 patients had active disease; 19 patients received a second or third stem cell transplantation (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>). Toxicity\u2010reduced conditioning regimens consisted of fludarabine or clofarabine (in active disease only), thiotepa, melphalan and serotherapy. Graft manipulation was carried out with immunomagnetic microbeads. Primary engraftment occurred in 88%, with a median time to reach &gt;1\u00b70\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l leucocytes, &gt;20\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l platelets and &gt;0\u00b71\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l T\u2010cells of 10, 11 and 50\u00a0days, respectively. After retransplantation, engraftment occurred in 100%. Acute graft\u2010versus\u2010host disease (Gv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> occurred in 20% and 7%, chronic Gv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> occurred in 21%. Both conditioning regimens had comparable toxicity. Transplant\u2010related mortality (<jats:styled-content style=\"fixed-case\">TRM<\/jats:styled-content>) was 8% at one year and 20% at 5\u00a0years. Event\u2010free survival at 3\u00a0years was: 25% (whole group), 46% (first, second or third complete remission [<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>], first <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>) vs. 8% (active disease, first <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>) and 20% (second or third <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>, any disease status). This approach allows first or subsequent haploidentical <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>s to be performed with low <jats:styled-content style=\"fixed-case\">TRM<\/jats:styled-content>. Patients in <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> may benefit from <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>, whereas the results in patients with active disease were poor.<\/jats:p>","DOI":"10.1111\/bjh.12810","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T12:55:01Z","timestamp":1393937701000},"page":"688-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Transplantation of <scp>CD<\/scp>3\/<scp>CD<\/scp>19 depleted allografts from haploidentical family donors in paediatric leukaemia"],"prefix":"10.1111","volume":"165","author":[{"given":"Peter","family":"Lang","sequence":"first","affiliation":[{"name":"Children's University Hospital University of Tuebingen Tuebingen 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