{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:22:35Z","timestamp":1778581355443,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>xtranodal <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ymphoma <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tudy <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup coordinated a phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> trial to evaluate the activity and safety of everolimus in marginal zone lymphomas (<jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content>s). Thirty patients with relapsed\/refractory <jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content>s received everolimus for six cycles or until dose\u2010limiting toxicity or progression. Median age was 71\u00a0years (range, 51\u201388\u00a0years). Twenty patients had extranodal, six splenic, four nodal <jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content>. Twenty\u2010four patients had stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>. Median number of prior therapies was two (range 1\u20135). Seventeen patients had early treatment discontinuation, in most cases due to toxicity. Median number of cycles was 4\u00b75 (range, 1\u201316). Among the 24 assessable patients, the overall response rate (<jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>) was 25% (95% confidence interval: 10\u201347). Grade 3\u20134 adverse events were neutropenia and thrombocytopenia (17% of patients, each), infections (17%), mucositis and odontogenic infections (13%) and lung toxicity (3%). The median response duration was 6\u00b78\u00a0months (range, 1\u00b74\u201311\u00b71+). After a median follow\u2010up of 14\u00b75\u00a0months, five deaths were reported: four deaths were due to lymphoma, one was due to toxicity. In an intent\u2010to\u2010treat analysis, the projected median progression\u2010free survival was 14\u00a0months. The moderate antitumour activity of everolimus in relapsed\/refractory <jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content>s and the observed toxicity limit its therapeutical applicability in these indolent entities. Lower doses of the drug and, perhaps, different strategies including combination with additional agents need to be explored.<\/jats:p>","DOI":"10.1111\/bjh.12845","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T09:23:02Z","timestamp":1402651382000},"page":"69-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Clinical activity of everolimus in relapsed\/refractory marginal zone <scp>B<\/scp>\u2010cell lymphomas: results of a phase <scp>II<\/scp> study of the <scp>I<\/scp>nternational <scp>E<\/scp>xtranodal <scp>L<\/scp>ymphoma <scp>S<\/scp>tudy <scp>G<\/scp>roup"],"prefix":"10.1111","volume":"166","author":[{"given":"Annarita","family":"Conconi","sequence":"first","affiliation":[{"name":"Division of Haematology Department of Translational Medicine Amedeo Avogadro University of Eastern Piedmont AOU Maggiore della Carit\u00e0 Novara Italy"},{"name":"Haematology Unit Department of Internal Medicine Ospedale degli Infermi Biella Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Raderer","sequence":"additional","affiliation":[{"name":"Division of Oncology Department of Internal Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Franceschetti","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Translational Medicine Amedeo Avogadro University of Eastern Piedmont AOU Maggiore della Carit\u00e0 Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Devizzi","sequence":"additional","affiliation":[{"name":"Medical Oncology Fondazione IRCCS Istituto Nazionale Tumori Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s J. 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