{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:09:26Z","timestamp":1772780966973,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Early recognition of children with chronic phase chronic myeloid leukaemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) at risk for developing a lymphoid blast crisis (Ly<jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>) is desirable, because therapy options in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>y<jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> are limited. We used Multiplex Ligation\u2010dependent Probe Amplification to determine whether <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphoid leukaemia\u2010specific copy number alterations (<jats:styled-content style=\"fixed-case\">CNA<\/jats:styled-content>s) (e.g. <jats:italic><jats:styled-content style=\"fixed-case\">IKZF<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">PAX<\/jats:styled-content>5<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CDKN<\/jats:styled-content>2A<\/jats:italic> deletions) could be detected in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> and may be used to predict disease progression to Ly<jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CNA<\/jats:styled-content>s were detected in all patients with <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\u2010Ly<jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>, but in none of the 77 patients with <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. Based on this study we conclude that <jats:styled-content style=\"fixed-case\">CNA<\/jats:styled-content>s remain a hallmark of disease progression.<\/jats:p>","DOI":"10.1111\/bjh.12850","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T06:15:08Z","timestamp":1395900908000},"page":"250-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>DNA<\/scp> copy number alterations mark disease progression in paediatric chronic myeloid leukaemia"],"prefix":"10.1111","volume":"166","author":[{"given":"Naomi E.","family":"van der Sligte","sequence":"first","affiliation":[{"name":"Division of Paediatric Oncology\/Haematology Department of Paediatrics Beatrix Children's Hospital University Medical Centre Groningen University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Krumbholz","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospital Erlangen Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Pastorczak","sequence":"additional","affiliation":[{"name":"Laboratory of Paediatric Oncology Radboud University Medical centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Scheijen","sequence":"additional","affiliation":[{"name":"Laboratory of Paediatric Oncology Radboud University Medical centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine T.","family":"Tauer","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospital \u201cCarl Gustav Carus\u201d Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Nowasz","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospital \u201cCarl Gustav Carus\u201d Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Sonneveld","sequence":"additional","affiliation":[{"name":"Dutch Childhood Oncology Group The Hague The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geertruida H.","family":"de Bock","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University Medical Centre Groningen University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiny G. 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