{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:42:13Z","timestamp":1794271333661,"version":"4.9.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinical Epidemiological Research Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Studies have reported a 1\u00b73\u2010 to 2\u00b72\u2010fold higher mortality rate among patients with primary immune thrombocytopenia (\n                    <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>\n                    ) compared to the general population. However, long\u2010term mortality estimates as well as cause\u2010specific mortality data are sparse. In our population\u2010based cohort of adult patients with newly diagnosed\n                    <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>\n                    and up to 37\u00a0years of follow\u2010up, the 5\u2010year, 10\u2010year and 20\u2010year mortality among the\n                    <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>\n                    patients was 22%, 34% and 49%, respectively. The mortality in the\n                    <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>\n                    cohort was consistently higher than in the in the general population cohort yielding an adjusted hazard ratio (\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    ) of 1\u00b75 [95% confidence interval (\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ): 1\u00b72\u20131\u00b78]. The adjusted\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    s of mortality due to cardiovascular disease, infection, bleeding and haematological cancer were 1\u00b75 (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    : 1\u00b71\u20131\u00b75), 2\u00b74 (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    : 1\u00b70\u20135\u00b77), 6\u00b72 (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    : 2\u00b78\u201313\u00b75) and 5\u00b77 (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    : 2\u00b71\u201315\u00b77), respectively, whereas mortality due to solid cancer and other causes were similar in\n                    <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>\n                    patients and the general population. We conclude that mortality rates among\n                    <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>\n                    patients are higher than in the general population, predominantly as a result of increased cardiovascular disease, infection, bleeding and haematological cancer cause\u2010specific mortalities.\n                  <\/jats:p>","DOI":"10.1111\/bjh.12869","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T04:59:32Z","timestamp":1396414772000},"page":"260-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Twenty\u2010year mortality of adult patients with primary immune thrombocytopenia: a Danish population\u2010based cohort study"],"prefix":"10.1111","volume":"166","author":[{"given":"Henrik","family":"Frederiksen","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus 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