{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:16:06Z","timestamp":1791134166474,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T00:00:00Z","timestamp":1397779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Management of the acute painful crisis (\n                    <jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>\n                    ) of sickle cell disease (\n                    <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                    ) remains unsatisfactory despite advances in the understanding and management of acute pain in other clinical settings. One reason for this is an unsophisticated approach to the use of opioid analgesics for pain management. This applies to haematologists who are responsible for developing acute sickle pain management protocols for their patients, and to health care staff in the acute care setting. The objective of this article is to evaluate the evidence for use of opioids in\n                    <jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>\n                    management. We have highlighted the possibilities for improving management by using alternatives to morphine, and intranasal (\n                    <jats:styled-content style=\"fixed-case\">IN<\/jats:styled-content>\n                    ) or transmucosal routes of administration for rapid onset of analgesia in the emergency department (\n                    <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>\n                    ). We suggest how experience gained in managing acute sickle pain in children could be extrapolated to adolescents and young adults. We have also questioned whether patients given strong opioids in the acute setting are being safely monitored and what resources are required to ensure efficacy, safety and patient satisfaction. We also identify aspects of care where there are significant differences of opinion, which require further study by randomized controlled trial.\n                  <\/jats:p>","DOI":"10.1111\/bjh.12879","type":"journal-article","created":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T05:26:59Z","timestamp":1397885219000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Management of the acute painful crisis in sickle cell disease\u2010 a re\u2010evaluation of the use of opioids in adult patients"],"prefix":"10.1111","volume":"166","author":[{"given":"Paul","family":"Telfer","sequence":"first","affiliation":[{"name":"Department of Haematology Royal London Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal","family":"Bahal","sequence":"additional","affiliation":[{"name":"Department of Anaesthetics Royal London Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Royal London Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Challands","sequence":"additional","affiliation":[{"name":"Department of Paediatric Anaesthetics Royal London Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fds035"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2007.09.033"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.8.2154.2154"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.03.020"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-383430"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-74"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20944"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2003.07.002"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20403"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216310392102"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199611000-00007"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22176"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544120-00006"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.05.015"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006297749"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer115"},{"key":"e_1_2_13_18_1","first-page":"CD003350","article-title":"Pain management for sickle cell disease","author":"Dunlop R.J.","year":"2006","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(02)00553-1"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2003.12.001"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-005-9042-3"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1989.tb05399.x"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)08462-6"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7281.261"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.140194"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2003.10.007"},{"issue":"1","key":"e_1_2_13_27_1","article-title":"Evaluation of an analgesia regime with intranasal diamorphine and oral morphine for acute sickle crisis pain in children","volume":"137","author":"Lahoz C.","year":"2007","journal-title":"British Journal of Haematology"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2004.02264.x"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7198.1585"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pec.0000106235.72265.29"},{"key":"e_1_2_13_31_1","unstructured":"MHRA(2013)Press release: MHRA confirms codeine not to be used in children under 12\u00a0years old.http:\/\/www.mhra.gov.uk\/NewsCentre\/Pressreleases\/CON287048[Accessed 23 November 2013]."},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22265"},{"key":"e_1_2_13_33_1","unstructured":"NCEPOD(2008)Sickle: A sickle crisis?http:\/\/www.ncepod.org.uk\/2008sc.htm[Accessed 23 November 2013]."},{"key":"e_1_2_13_34_1","unstructured":"NHS Sickle Cell and Thalassaemia Screening Programmes(2010)Sickle Cell Disease in Childhood. Standards and Guidelines for Clinical Care.http:\/\/sct.screening.nhs.uk[Accessed 23 November 2013]."},{"key":"e_1_2_13_35_1","unstructured":"NICE(2012)Sickle cell acute painful episode: Management of an acute painful sickle cell episode in hospital. NICE Clinical Guideline 143.http:\/\/guidance.nice.org.uk\/CG143[Accessed 23 November 2013]."},{"key":"e_1_2_13_36_1","unstructured":"Olujohungbe A. Bennett L. Chapman C. Davis B. Howard J. Ryan K. Pancham S.&Yardumian A.(2008)Standards for the Clinical Care of Adults with Sickle Cell Disease in the UK.http:\/\/sct.screening.nhs.uk\/getdata.php?id=10991[Accessed 23 November 2013]."},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049463712438493"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2011.11.018"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903368310"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04193.x"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.058859"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199802000-00006"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.138875"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12190"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7496.869"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.14.2.70"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.12879","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.12879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:00:06Z","timestamp":1696338006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.12879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,18]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/bjh.12879"],"URL":"https:\/\/doi.org\/10.1111\/bjh.12879","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,18]]},"assertion":[{"value":"2013-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}