{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:59:31Z","timestamp":1791896371759,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Leukaemia and Lymphoma Research (UK)"},{"DOI":"10.13039\/501100000265","name":"Medical Research Council (UK)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We investigated the outcome for children and young people with Early T\u2010precursor acute lymphoblastic leukaemia (ETP\u2010ALL), a recently described poor prognosis sub\u2010group of T\u2010ALL, treated on a contemporary protocol, UKALL 2003. After a median follow\u2010up of 4\u00a0years and 10\u00a0months, the ETP sub\u2010group, representing 16% of T\u2010ALL patients, had non\u2010significantly inferior 5\u2010year event\u2010free survival (76\u00b77% vs. 84\u00b76%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b72) and overall survival (82\u00b74% vs. 90\u00b79%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b71), and a higher relapse rate (18\u00b76% vs. 9\u00b76%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b71) compared to typical T\u2010ALL. ETP\u2010ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally.<\/jats:p>","DOI":"10.1111\/bjh.12882","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T06:36:45Z","timestamp":1396939005000},"page":"421-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":211,"title":["Outcome for children and young people with <scp>E<\/scp>arly <scp>T<\/scp>\u2010cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, <scp>UKALL<\/scp> 2003"],"prefix":"10.1111","volume":"166","author":[{"given":"Katharine","family":"Patrick","sequence":"first","affiliation":[{"name":"Sheffield Children's Hospital Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Wade","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Goulden","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Mitchell","sequence":"additional","affiliation":[{"name":"John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony V.","family":"Moorman","sequence":"additional","affiliation":[{"name":"Leukaemia Research Cytogenetics Group Northern Institute for Cancer Research Newcastle University Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Rowntree","sequence":"additional","affiliation":[{"name":"University Hospital Wales Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Jenkinson","sequence":"additional","affiliation":[{"name":"Department of Haematology UCL Cancer Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Hough","sequence":"additional","affiliation":[{"name":"University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Vora","sequence":"additional","affiliation":[{"name":"Sheffield Children's Hospital Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70314-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-012-0224-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2010.08.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2011.49"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053190"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-491092"},{"key":"e_1_2_7_8_1","first-page":"908","article-title":"Improved outcome for children and young adults with T\u2010cell acute lymphoblastic leukaemia (ALL): results of the United Kingdom Medical Research Council (MRC) Trial UKALL 2003","volume":"112","author":"Vora A.","year":"2008","journal-title":"Blood (ASH Annual Meeting 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