{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:10:26Z","timestamp":1781277026209,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In women with pre\u2010existing immune thrombocytopenic purpura (<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>), the effect of pregnancy on the course of the disease is poorly known. We performed a dual\u2010centre retrospective cohort study of 118 pregnancies in 82 women with primary <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>. In early pregnancy, the platelet count was &lt;100\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l in 35\u00b76% of pregnancies. During pregnancy the median platelet count nadir was 66\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l (25th\u201375th percentile: 42\u2013117), with platelet count &lt;30\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l for 26 pregnancies (22%). In 49% of pregnancies, a significant decrease of the platelet count required treatment at least transiently in preparation for delivery. At the time of delivery, the median platelet count was 110\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l (77\u2013155). Compared to before pregnancy, at 3\u00a0months post\u2010partum, only 11% of pregnancies [95% confidence interval (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 6\u00b78\u201320\u00b72] showed disease worsening. Previous splenectomy was the only factor significantly associated with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> worsening after pregnancy (53\u00b79% vs. 10\u00b73%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). For 8\u00b73% of the pregnancies (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 3\u00b78\u201315\u00b71), neonatal thrombocytopenia required treatment, especially in case of previous maternal splenectomy (adjusted odds ratio 16\u00b77, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2\u00b761\u2013106). The overall risk of exacerbation of <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> and severe thrombocytopenia during pregnancy is acceptable.<\/jats:p>","DOI":"10.1111\/bjh.12976","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T13:13:39Z","timestamp":1403615619000},"page":"929-935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Effect of pregnancy on the course of immune thrombocytopenia: a retrospective study of 118 pregnancies in 82 women"],"prefix":"10.1111","volume":"166","author":[{"given":"Valentine","family":"Loustau","sequence":"first","affiliation":[{"name":"APHP Henri Mondor Hospital, Department of Internal Medicine French National Referral Centre for Adult's Immune Cytopeniasl Creteil France"},{"name":"UPEC Medicine Faculty Creteil 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Centre for Adult's Immune Cytopeniasl Creteil France"},{"name":"UPEC Medicine Faculty Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Touboul","sequence":"additional","affiliation":[{"name":"Centre Hospitalier InterCommunal de Creteil Department of Obstetrics\u2010Gynecology Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Languille","sequence":"additional","affiliation":[{"name":"APHP Henri Mondor Hospital, Department of Internal Medicine French National Referral Centre for Adult's Immune Cytopeniasl Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Loustau","sequence":"additional","affiliation":[{"name":"Simone Veil Hospital Department of Public Health Eaubonne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bierling","sequence":"additional","affiliation":[{"name":"APHP Henri Mondor Hospital, Department of Internal Medicine French National Referral Centre for Adult's Immune Cytopeniasl Creteil France"},{"name":"UPEC Medicine Faculty Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam","family":"Haddad","sequence":"additional","affiliation":[{"name":"UPEC Medicine Faculty Creteil France"},{"name":"Centre Hospitalier InterCommunal de Creteil Department of Obstetrics\u2010Gynecology Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Godeau","sequence":"additional","affiliation":[{"name":"APHP Henri Mondor Hospital, Department of Internal Medicine French National Referral Centre for Adult's Immune Cytopeniasl Creteil France"},{"name":"UPEC Medicine Faculty Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Pourrat","sequence":"additional","affiliation":[{"name":"La Miletrie University Hospital Department of Internal Medicine Poitiers 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