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Significant advances in targeted therapy with the development and use in children of tyrosine kinase inhibitors and the ability to monitor and understand the prognostic significance of minimal residual disease by standardized molecular techniques has shifted the management of this condition from bone marrow transplantation as the main therapeutic modality to individualized treatment for each patient based on achieving specific milestones. The physiological changes occurring during childhood, particularly those affecting growth and development and the long\u2010term use of treatment, pose specific challenges in this age group, which we are only beginning to understand.<\/jats:p>","DOI":"10.1111\/bjh.12977","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:52:50Z","timestamp":1404175970000},"page":"33-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Managing children with chronic myeloid leukaemia (<scp>CML<\/scp>)"],"prefix":"10.1111","volume":"167","author":[{"given":"Josu","family":"de la Fuente","sequence":"first","affiliation":[{"name":"Paediatrics Department Saint Mary Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Baruchel","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology Hopital Robert Debr\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Biondi","sequence":"additional","affiliation":[{"name":"M. 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