{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:29:27Z","timestamp":1788200967954,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["PI13\/00557"],"award-info":[{"award-number":["PI13\/00557"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Bone marrow histology is included in the diagnostic criteria of myeloproliferative neoplasms (<jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>s). However, some concerns have emerged about its reproducibility. To evaluate the diagnostic accuracy of histology and to assess its correlation with presence of mutations and clinical outcomes, two pathologists reviewed the bone marrow biopsies corresponding to 211 patients with <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>. Despite the low agreement in the evaluation of individual histopathological characteristics, the concordance among pathologists when establishing the diagnosis was good (Kappa index 0\u00b767). The specificity of histology was 100%, 98\u00b75% and 98% in polycythaemia vera (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>), essential thrombocythaemia (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) and primary myelofibrosis (<jats:styled-content style=\"fixed-case\">PMF<\/jats:styled-content>), respectively, whereas the sensitivity of histological diagnosis was low in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> (32\u00b75% and 54% respectively) and acceptable in <jats:styled-content style=\"fixed-case\">PMF<\/jats:styled-content> (75%). Thirteen out of 146 (9%) patients with clinical <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> were diagnosed as prefibrotic <jats:styled-content style=\"fixed-case\">PMF<\/jats:styled-content>. No histological agreement or <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> otherwise unspecified was more frequently observed in <jats:styled-content style=\"fixed-case\"><jats:italic>JAK<\/jats:italic><\/jats:styled-content><jats:italic>2<\/jats:italic> V617F\u2010positive <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> than in <jats:styled-content style=\"fixed-case\"><jats:italic>CALR<\/jats:italic><\/jats:styled-content>\u2010mutated cases, whereas megakaryocytic abnormalities and prefibrotic <jats:styled-content style=\"fixed-case\">PMF<\/jats:styled-content> were more frequently observed in <jats:styled-content style=\"fixed-case\"><jats:italic>CALR<\/jats:italic><\/jats:styled-content>\u2010mutated <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>. In conclusion, histological criteria of <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> have a limited diagnostic accuracy due to low sensitivity. Patients with <jats:styled-content style=\"fixed-case\"><jats:italic>JAK<\/jats:italic><\/jats:styled-content><jats:italic>2<\/jats:italic> V617F\u2010positive <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> have a heterogeneous histology while <jats:styled-content style=\"fixed-case\"><jats:italic>CALR<\/jats:italic><\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> is associated with megakaryocyte abnormalities and prefibrotic <jats:styled-content style=\"fixed-case\">PMF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.12990","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T13:14:18Z","timestamp":1403615658000},"page":"911-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["<scp>WHO<\/scp>\u2010histological criteria for myeloproliferative neoplasms: reproducibility, diagnostic accuracy and 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