{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:04:39Z","timestamp":1785445479425,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The clinical characteristics and prognostic relevance of acute myeloid leukaemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>) with myelodysplastic features remains to be clarified in children. We prospectively examined 443 newly diagnosed patients in a multicentre clinical trial for paediatric <jats:italic>de novo <\/jats:italic><jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>, and found \u2018<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> with myelodysplasia\u2010related changes\u2019 (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRC<\/jats:styled-content>) according to the 2008 World Health Organization classification in 93 (21\u00b70%), in whom 59 were diagnosed from myelodysplasia\u2010related cytogenetics alone, 28 from multilineage dysplasia alone and six from a combination of both. Compared with 111 patients with \u2018<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>, not otherwise specified\u2019 (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>), patients with \u2018<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRC<\/jats:styled-content>\u2019 presented at a younger age, with a lower white blood cell count, higher incidence of 20\u201330% bone marrow blasts, unfavourable cytogenetics and a lower frequency of Fms\u2010like tyrosine kinase 3 internal tandem duplication (<jats:italic><jats:styled-content style=\"fixed-case\">FLT<\/jats:styled-content>3<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">ITD<\/jats:styled-content>), <jats:italic><jats:styled-content style=\"fixed-case\">NPM<\/jats:styled-content>1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">CEBPA<\/jats:styled-content><\/jats:italic> mutations. Complete remission rate and 3\u2010year probability of event\u2010free survival were significantly worse in \u2018<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRC<\/jats:styled-content>\u2019 patients (67\u00b77 vs. 85\u00b76%, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b701, 37\u00b71% vs. 53\u00b78%<jats:italic>, P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b702, respectively), but 3\u2010year overall survival and relapse\u2010free survival were comparable with \u2018<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\u2019 patients. By multivariate analysis, <jats:italic><jats:styled-content style=\"fixed-case\">FLT<\/jats:styled-content>3<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">ITD<\/jats:styled-content> was solely associated with worse overall survival. These results support the distinctive features of the category \u2018<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRC<\/jats:styled-content>\u2019 even in children.<\/jats:p>","DOI":"10.1111\/bjh.12993","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T07:12:56Z","timestamp":1404803576000},"page":"80-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Acute myeloid leukaemia with myelodysplastic features in children: a report of Japanese Paediatric Leukaemia\/Lymphoma Study Group"],"prefix":"10.1111","volume":"167","author":[{"given":"Akitoshi","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Department of Paediatrics St. Marianna University School of Medicine Kawasaki 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