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We performed a matched\u2010pair analysis to evaluate the prognostic impact of several histopathological features in this distinct Hodgkin lymphoma subtype. Lymph node samples of <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content> patients were tested for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>15, IgD, phosphorylated <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>6, <jats:styled-content style=\"fixed-case\">ICOS<\/jats:styled-content> and Epstein\u2013Barr virus status of the malignant lymphocyte\u2010predominant cells as well as epithelioid cell clusters and activated T cells in the microenvironment. None of these features was associated with a particular clinical outcome. However, patients presenting with epithelioid cell clusters showed a non\u2010significant trend towards a lower relapse rate, justifying further evaluation of this marker.<\/jats:p>","DOI":"10.1111\/bjh.12997","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T07:59:48Z","timestamp":1403769588000},"page":"238-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Histopathological features and their prognostic impact in nodular lymphocyte\u2010predominant Hodgkin lymphoma \u2013 a matched pair analysis from the German Hodgkin Study Group (GHSG)"],"prefix":"10.1111","volume":"167","author":[{"given":"Sylvia","family":"Hartmann","sequence":"first","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis 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