{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:22:14Z","timestamp":1787595734838,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The efficacy of a fixed\u2010dose rituximab schedule was prospectively explored in primary\/acute refractory, relapsed or chronic (platelet count &gt;10\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l and \u226450\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l) idiopathic thrombocytopenic purpura (<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>). Patients received two doses of rituximab (1000\u00a0mg) on days 1 and 15 and were followed\u2010up on weeks 1\u20138, 12, 26, 39 and 52. A total of 122 patients were included in the safety population; efficacy was analysed in 108 patients. Overall response rate (<jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>) at week 8, defined as the proportion of patients achieving complete response (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>; platelet count &gt;150\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l) or partial response (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>; platelet count &gt;50\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l) was 44%. Therapeutic response, defined as achieving a response at week 8, with at least a minor response (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>; platelet count &gt;30\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l), sustained up to weeks 26 and 52 and accompanied by a reduction in <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> medications, was achieved in 44% (week 26) and 35% (week 52) of patients, respectively. Treatment was well tolerated with no safety concerns. While this study failed to meet its primary endpoint of an <jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content> of 50%, the efficacy of two fixed doses of rituximab appear to provide similar efficacy to the standard 375\u00a0mg\/m<jats:sup>2<\/jats:sup> four\u2010dose schedule in relapsed\/chronic <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.13029","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T09:28:34Z","timestamp":1405070914000},"page":"243-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A multi\u2010centre, single\u2010arm, open\u2010label study evaluating the safety and efficacy of fixed dose rituximab in patients with refractory, relapsed or chronic idiopathic thrombocytopenic purpura (R\u2010<scp>ITP<\/scp>1000 study)"],"prefix":"10.1111","volume":"167","author":[{"given":"Huyen","family":"Tran","sequence":"first","affiliation":[{"name":"Monash Medical Centre Clayton Vic. 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