{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T04:39:38Z","timestamp":1718858378442},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T00:00:00Z","timestamp":1405296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Low endogenous erythropoietin levels and limited red blood cell transfusion history can predict response to erythropoiesis\u2010stimulating agents in anaemic patients with myelodysplastic syndromes (<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>). The relationship between endogenous thrombopoietin (<jats:styled-content style=\"fixed-case\">THPO<\/jats:styled-content>) levels and platelet response to romiplostim is unknown. Variables including baseline endogenous <jats:styled-content style=\"fixed-case\">THPO<\/jats:styled-content> levels, transfusion needs, and platelet response were analysed in a randomized trial of 250 thrombocytopenic, lower\u2010risk <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> patients (International Prognostic Scoring System low\/intermediate\u20101). A predictive scoring system was developed based on log\u2013likelihood ratios and logistic coefficients. Patients with <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\u2013P (haematological improvement \u2013 platelets) responses had lower mean baseline <jats:styled-content style=\"fixed-case\">THPO<\/jats:styled-content> levels (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70497) and were more likely to have &lt;6 platelet units transfused in the past year (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70027), as did patients with platelet responses \u226550% of weeks on romiplostim (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7001 and <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70037, respectively). A model for predicting response to romiplostim was developed and validated in a separate <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> cohort (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>72). Patients in low\u2010, intermediate\u2010, and high\u2010response groups had response rates of 17\u00b74%, 29\u00b76%, and 50\u00b77%, respectively, for <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\u2010P, and 17\u00b74%, 33\u00b78%, and 65\u00b72%, respectively, for \u226550% response. For thrombocytopenic patients with lower\u2010risk <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>, lower baseline <jats:styled-content style=\"fixed-case\">THPO<\/jats:styled-content> levels (&lt;500\u00a0pg\/ml) and limited platelet transfusion history predicted a greater likelihood of a subsequent platelet response to romiplostim.<\/jats:p>","DOI":"10.1111\/bjh.13037","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T16:10:51Z","timestamp":1405440651000},"page":"337-345","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Development and validation of a model to predict platelet response to romiplostim in patients with lower\u2010risk myelodysplastic syndromes"],"prefix":"10.1111","volume":"167","author":[{"given":"Mikkael A.","family":"Sekeres","sequence":"first","affiliation":[{"name":"Leukemia Program Cleveland Clinic Taussig Cancer Institute Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristoteles","family":"Giagounidis","sequence":"additional","affiliation":[{"name":"Department of Haematology, Oncology and Palliative Care Marien Hospital D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagop","family":"Kantarjian","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam J.","family":"Mufti","sequence":"additional","affiliation":[{"name":"King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Fenaux","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie clinique Hopital Avicenne Universite Paris XIII Bobigny France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Jia","sequence":"additional","affiliation":[{"name":"Amgen Inc. San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen S.","family":"Yang","sequence":"additional","affiliation":[{"name":"Amgen Inc. Thousand Oaks CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Platzbecker","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I University Hospital Carl Gustav Carus Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2003.05.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054626"},{"key":"e_1_2_8_4_1","first-page":"3671","article-title":"Report of an international working group to standardize response criteria for myelodysplastic syndromes","volume":"96","author":"Cheson B.D.","year":"2000","journal-title":"Blood"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4149"},{"key":"e_1_2_8_6_1","first-page":"2772","article-title":"Update of an open\u2010label extension study 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