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We previously demonstrated that treatment with L\u2010Leucine resulted in a marked improvement in anaemia in disease models. To determine if the L\u2010Leucine effect was Tp53\u2010dependent, we used antisense <jats:styled-content style=\"fixed-case\">MO<\/jats:styled-content>s to <jats:italic>rps19<\/jats:italic> and <jats:italic>rps14<\/jats:italic> in zebrafish; expression of <jats:italic>tp53<\/jats:italic> and its downstream target <jats:italic>cdkn1a<\/jats:italic> remained elevated following L\u2010leucine treatment. We confirmed this observation in human <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cells. L\u2010Leucine thus alleviates anaemia in <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>\u2010deficient cells in a <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53\u2010independent manner.<\/jats:p>","DOI":"10.1111\/bjh.13069","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T10:18:05Z","timestamp":1407406685000},"page":"524-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["L\u2010Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q\u2010 syndrome in a <scp>TP<\/scp>53\u2010independent way"],"prefix":"10.1111","volume":"167","author":[{"given":"Anupama","family":"Narla","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Lucile Packard Children's Hospital Stanford University School of Medicine Stanford CA USA"},{"name":"Division of Hematology Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth M.","family":"Payne","sequence":"additional","affiliation":[{"name":"University College London London UK"},{"name":"National Institute for Health Research University College London Hospitals Biomedical Research Centre London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmalee","family":"Abayasekara","sequence":"additional","affiliation":[{"name":"Division of Hematology Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slater N.","family":"Hurst","sequence":"additional","affiliation":[{"name":"Division of Hematology Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Raiser","sequence":"additional","affiliation":[{"name":"Division of Hematology Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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