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The adverse prognostic factors among <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>\u2010negative patients remain unknown. We analysed the <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>02 study cohort to identify demographic and genetic prognostic factors. Among the presenting features, certain 11q23 abnormalities, such as t(6;11) and t(10;11), acute megakaryoblastic leukaemia without the t(1;22), and age \u226510\u00a0years were associated with inferior outcome in patients who had <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>\u2010negative status after either remission induction I or <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. By contrast, those with rearrangement of <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> genes had superior outcome. Our study identifies patient populations for whom close post\u2010remission <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> monitoring to detect and treat emerging relapse and adjustment in treatment intensity might be indicated.<\/jats:p>","DOI":"10.1111\/bjh.13107","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T06:25:33Z","timestamp":1409207133000},"page":"94-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy"],"prefix":"10.1111","volume":"168","author":[{"given":"Seth E.","family":"Karol","sequence":"first","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis TN 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