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To examine the association between microparticles and <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>, we compared plasma microparticle levels in 20 patients with and without <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content>. Microparticles were quantified using nanoparticle tracking analysis and found to be 2\u00b73\u2010fold higher in patients with <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content> compared to patients without <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content>, and 2\u00b75\u2010fold higher than in healthy controls. These results suggest that microparticles may be a clinically useful biomarker of <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>. Further investigations are needed to determine the functional relevance of microparticles in the pathogenesis of <jats:styled-content style=\"fixed-case\">ONFH<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.13110","type":"journal-article","created":{"date-parts":[[2014,9,6]],"date-time":"2014-09-06T07:04:06Z","timestamp":1409987046000},"page":"135-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Microparticles as biomarkers of osteonecrosis of the hip in sickle cell disease"],"prefix":"10.1111","volume":"168","author":[{"given":"Anne","family":"Marsh","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology UCSF Benioff Children's Hospital Oakland Oakland CA USA"},{"name":"Children's Hospital Oakland Research Institute Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Schiffelers","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry &amp; Haematology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"Kuypers","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Larkin","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginny","family":"Gildengorin","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"van Solinge","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry &amp; Haematology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology UCSF Benioff Children's Hospital Oakland Oakland CA USA"},{"name":"Children's Hospital Oakland Research Institute Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.008938"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90295-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680490278240"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.04.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-013-1028-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1160\/TH06-08-0436","article-title":"Interaction of an annexin V homodimer (Diannexin) with phosphatidylserine on cell surfaces and consequent antithrombotic activity","volume":"97","author":"Kuypers F.A.","year":"2007","journal-title":"Journal of Thrombosis & Haemostasis"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-480277"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22103"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111213252104"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505790200"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0693"},{"key":"e_1_2_7_13_1","first-page":"947","article-title":"Sickle cell disease and silent avascular necrosis of the hip","volume":"73","author":"Ware H.E.","year":"1991","journal-title":"Journal of Bone & Joint Surgery (British Volume)"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00627.x"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.13110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.13110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T09:55:59Z","timestamp":1696326959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.13110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,6]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/bjh.13110"],"URL":"https:\/\/doi.org\/10.1111\/bjh.13110","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,6]]},"assertion":[{"value":"2014-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}