{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T07:09:41Z","timestamp":1794553781169,"version":"4.9.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>) patients are at increased risk of red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) alloimmunization. Recipient inflammatory state at time of transfusion has been shown to regulate alloimmunization in murine models, but evidence is lacking in<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>patients. We retrospectively studied a cohort of alloimmunized<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>patients to determine the influence of pro\u2010inflammatory<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\u2010related complications at time of transfusion on alloimmunization. For each transfusion, the presence of pro\u2010inflammatory state, degree of<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>antigen matching, unit age, storage solution and alloantibody detection date were ascertained. Transfusion\u2010associated pro\u2010inflammatory events were compared between transfusions resulting and not resulting in new alloantibodies. Univariate analysis and multivariate logistic regression were performed. Fifty\u2010two patients received 3166 pre\u2010storage leuco\u2010reduced transfusions of which 128 resulted in alloantibodies. Transfusions during inflammatory events were associated with increased alloantibody risk on univariate and multivariate analysis; acute chest syndrome and vaso\u2010occlusive crisis showed strongest associations with alloimmunization. Increased antigen matching demonstrated a protective effect on alloimmunization (univariate and multivariate analysis). Although an association was seen between citrate\u2010phosphate\u2010dextrose (adenine) stored units and alloimmunization on univariate analysis, no effect was found on multivariate analysis. Identifying recipient pro\u2010inflammatory states at time of transfusion that promote alloimmunization can impact<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>unit selection decisions for<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>patients at risk for alloimmunization.<\/jats:p>","DOI":"10.1111\/bjh.13123","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T06:51:02Z","timestamp":1411714262000},"page":"291-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":203,"title":["Red blood cell alloimmunization is influenced by recipient inflammatory state at time of transfusion in patients with sickle cell disease"],"prefix":"10.1111","volume":"168","author":[{"given":"Ross M.","family":"Fasano","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine Children's National Medical Centre Washington DC USA"},{"name":"Department of Haematology Children's National Medical Centre Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett S.","family":"Booth","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Centre Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Children's National Medical Centre Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University School of Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University School of Medicine Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Riehm","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Haematology Children's National Medical Centre Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi L. 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