{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:46:20Z","timestamp":1791499580210,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fetal Maternal Research Foundation Leiden","award":["n.a."],"award-info":[{"award-number":["n.a."]}]},{"name":"Sanquin Blood Supply","award":["PPOC07-029"],"award-info":[{"award-number":["PPOC07-029"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Red blood cell (\n                    <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\n                    ) antibodies can persist for decades or decrease quickly to undetectable levels. Antibody persistence has not been systematically studied. Women whose children are treated with intrauterine transfusions (\n                    <jats:styled-content style=\"fixed-case\">IUT<\/jats:styled-content>\n                    ) for haemolytic disease of the fetus (\n                    <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>\n                    ) often produce additional antibodies, which can be evoked by the intrauterine transfusion or by fetomaternal haemorrhage during the procedure. Factors associated with persistence of both the antibodies responsible for\n                    <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>\n                    and additional antibodies were studied in 260 women whose children were treated with\n                    <jats:styled-content style=\"fixed-case\">IUT<\/jats:styled-content>\n                    between 1988 and 2008. They possessed 499 (205 anti\u2010D and 294 non\u2010D) antibodies after the last\n                    <jats:styled-content style=\"fixed-case\">IUT<\/jats:styled-content>\n                    . After a median follow\u2010up of 8\u00b77\u00a0years, all 260 antibodies primarily responsible for\n                    <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>\n                    had persisted. Additional antibodies directed against antigens of the children persisted in 70\u00b76%, and in 32\u00b73% if they were not child\u2010specific (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b7001). Antibodies induced by irradiated\n                    <jats:styled-content style=\"fixed-case\">IUT<\/jats:styled-content>\n                    persisted in only 7\u00b71%. Multivariate analyses showed that non\u2010\n                    <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>\n                    antibody persistence was dependent on the antibody titre and specificity. In conclusion, persistence of antibodies mainly depends on antibody strength and specificity. Difference between fetal or non\u2010fetal immunogens suggests maintenance of antigenic stimulation possibly by long\u2010term fetomaternal chimerism.\n                  <\/jats:p>","DOI":"10.1111\/bjh.13130","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T02:14:30Z","timestamp":1411352070000},"page":"443-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Factors associated with persistence of red blood cell antibodies in woman after pregnancies complicated by fetal alloimmune haemolytic disease treated with intrauterine transfusions"],"prefix":"10.1111","volume":"168","author":[{"given":"Esther P.","family":"Verduin","sequence":"first","affiliation":[{"name":"Centre for Clinical Transfusion Research Sanquin Research Leiden the Netherlands"},{"name":"Department of Immunohematology and Blood Transfusion Leiden University Medical Centre Leiden the Netherlands"},{"name":"Jon J van Rood Centre for Clinical Transfusion Research Sanquin\u2010Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke","family":"Brand","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Leiden University Medical Centre Leiden the Netherlands"},{"name":"Jon J van Rood Centre for Clinical Transfusion Research Sanquin\u2010Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo M. 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