{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:27:35Z","timestamp":1773185255431,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chronic lymphocytic leukaemia (<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>) occurs rarely with pregnancy and monoclonal B\u2010Lymphocytosis (<jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>) has not previously been described in this setting. <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> is predominantly a disease of the elderly and affects men twice as often as women and hence only an estimated 2% of patients are females of childbearing age. We identified only five reported cases of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> in pregnancy in the literature. We describe two additional cases, plus three other women with <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> dealing with pregnancy\u2010related decisions. We review the literature and discuss proposals for management and issues that arise in this relatively uncommon occurrence. In contrast to many other haematological malignancies where longer remissions are typically associated with a lower risk of relapse, most patients with <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> who require treatment will ultimately relapse with current therapy. This complex setting requires careful consideration and well informed patients to assist with decisions related to pregnancy.<\/jats:p>","DOI":"10.1111\/bjh.13134","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T06:05:47Z","timestamp":1411625147000},"page":"350-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Chronic lymphocytic leukaemia, monoclonal <scp>B<\/scp>\u2010lymphocytosis and pregnancy: five cases, a literature review and discussion of management"],"prefix":"10.1111","volume":"168","author":[{"given":"Nada","family":"Hamad","sequence":"first","affiliation":[{"name":"Department of Haematology Royal North Shore Hospital, St Leonards Sydney NSW Australia"},{"name":"Kolling Institute University of Sydney, St Leonards Sydney NSW Australia"},{"name":"Chronic Lymphocytic Leukaemia Australian Research Consortium (CLLARC) Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kliman","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal North Shore Hospital, St Leonards Sydney NSW Australia"},{"name":"Kolling Institute University of Sydney, St Leonards Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. Giles","family":"Best","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal North Shore Hospital, St Leonards Sydney NSW Australia"},{"name":"Kolling Institute University of Sydney, St Leonards Sydney NSW Australia"},{"name":"Chronic Lymphocytic Leukaemia Australian Research Consortium (CLLARC) Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melody","family":"Caramins","sequence":"additional","affiliation":[{"name":"Departments of Haematology and Genetics Laverty Pathology Sydney NSW Australia"},{"name":"School of Medical Sciences University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Hertzberg","sequence":"additional","affiliation":[{"name":"Chronic Lymphocytic Leukaemia Australian Research Consortium (CLLARC) Sydney NSW Australia"},{"name":"Department of Haematology Prince of Wales Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lindeman","sequence":"additional","affiliation":[{"name":"Chronic Lymphocytic Leukaemia Australian Research Consortium (CLLARC) Sydney NSW Australia"},{"name":"Department of Haematology Prince of Wales Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ric","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Royal North Shore Hospital, St Leonards Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen P.","family":"Mulligan","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal North Shore Hospital, St Leonards Sydney NSW Australia"},{"name":"Kolling Institute University of Sydney, St Leonards Sydney NSW Australia"},{"name":"Chronic Lymphocytic Leukaemia Australian Research Consortium (CLLARC) Sydney NSW Australia"},{"name":"Departments of Haematology and Genetics Laverty Pathology Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2011.01.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970117)70:2<155::AID-IJC3>3.0.CO;2-W"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0723-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.05.019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27560"},{"key":"e_1_2_8_7_1","first-page":"2831","article-title":"Proposal of a prognostic score for previously untreated patients with chronic lymphocytic leukemia based on an overall survival analysis of three German CLL study group phase III trials","volume":"118","author":"Bahlo J.","year":"2011","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987551"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830380316"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2405092"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90466-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.9348"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61348-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e318236e9f9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089168407000412"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-452607"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2011.527331"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01466-4"},{"key":"e_1_2_8_19_1","first-page":"423","article-title":"The UK Medical Research Council CLL trials 1 and 2","volume":"30","author":"Catovsky D.","year":"1988","journal-title":"Nouvelle Revue Francaise D Hematologie"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-295444"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009355157"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70062-5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e318236e68a"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.08.061"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/393864"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9869-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1970.tb00774.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70797-5"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.10.007"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(05)80016-1"},{"key":"e_1_2_8_31_1","first-page":"435","article-title":"Extended follow up of the CLL8 protocol, a randomized phase\u2010III trial of the German CLL study group (GCLLSG) comparing fludarabine and cyclophosphamide (FC) to FC plus rituximab (FCR) for previously untreated patients with chronic lymphocytic leukemia (CLL): results on survival, progression\u2010free survival, delayed neutropenias and secondary malignancies confirm superiority of the FCR regimen","volume":"120","author":"Fischer K.","year":"2012","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830220213"},{"key":"e_1_2_8_33_1","first-page":"40","article-title":"Cancer in pregnancy: maternal and fetal implications on decision\u2010making","volume":"32","author":"Gambino A.","year":"2011","journal-title":"European Journal of Gynaecological Oncology"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2012.01.003"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-207126"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10216"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-093906"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61381-5"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldn034"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00409-6"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.5.610"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404802"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00214.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/271363"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.72.5.874"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0897.2002.1o041.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2165\/11596240-000000000-00000"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-283580"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.666542"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24248"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.598250"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.547963"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211481"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15260-9"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03300240036023"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008135"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa075290"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000150346.42901.07"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2008.03.006"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02882.x"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000063408"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)38843-5"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198010000-00040"},{"key":"e_1_2_8_64_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S.H.","year":"2008"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-140582"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.2801"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10060"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401799"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-423194"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.13134","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.13134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T01:24:04Z","timestamp":1696296244000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.13134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,25]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/bjh.13134"],"URL":"https:\/\/doi.org\/10.1111\/bjh.13134","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,25]]},"assertion":[{"value":"2014-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}