{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T08:54:29Z","timestamp":1770800069354,"version":"3.50.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Associazione Italiana contro le Leucemie, Linfomi e Mieloma (AIL)"},{"name":"Italian Group for Adult Hematologic Diseases (GIMEMA)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Summary<\/jats:title>The primary objective of this study was to investigate factors associated with fatigue severity in newly diagnosed patients with higher\u2010risk myelodysplastic syndromes (MDS<\/jats:styled-content>). The secondary objectives were to assess symptom prevalence and to examine the relationships between fatigue, quality of life (Q<\/jats:styled-content>oL<\/jats:styled-content>) and overall symptom burden in these patients. The analyses were conducted in 280 higher\u2010risk MDS<\/jats:styled-content> patients. Pre\u2010treatment patient\u2010reported fatigue was evaluated with the F<\/jats:styled-content>unctional A<\/jats:styled-content>ssessment of C<\/jats:styled-content>hronic I<\/jats:styled-content>llness T<\/jats:styled-content>herapy (FACIT<\/jats:styled-content>)\u2010F<\/jats:styled-content>atigue scale and Q<\/jats:styled-content>oL<\/jats:styled-content> was assessed with the E<\/jats:styled-content>uropean O<\/jats:styled-content>rganization for R<\/jats:styled-content>esearch and T<\/jats:styled-content>reatment of C<\/jats:styled-content>ancer Q<\/jats:styled-content>uality of L<\/jats:styled-content>ife Q<\/jats:styled-content>uestionnaire\u2010C<\/jats:styled-content>ore 30 (EORTC QLQ<\/jats:styled-content>\u2010C<\/jats:styled-content>30). Female gender (P<\/jats:italic>\u00a0=\u00a00\u00b7018), poor performance status (i.e., ECOG<\/jats:styled-content> of 2\u20134) (P<\/jats:italic>\u00a0<\u00a00\u00b7001) and lower levels of haemoglobin (H<\/jats:styled-content>b) (P<\/jats:italic>\u00a0=\u00a00\u00b7026) were independently associated with higher fatigue severity. The three most prevalent symptoms were as follows: fatigue (92%), dyspnoea (63%) and pain (55%). Patients with higher levels of fatigue also had greater overall symptom burdens. The mean global Q<\/jats:styled-content>oL<\/jats:styled-content> scores of patients with the highest versus those with the lowest levels of fatigue were 29\u00b72 [standard deviation (SD<\/jats:styled-content>), 18\u00b73] and 69\u00b70 (SD<\/jats:styled-content>, 18\u00b78), respectively and this difference was four times the magnitude of a clinically meaningful difference. Patient\u2010reported fatigue severity revealed the effects of disease burden on overall Q<\/jats:styled-content>oL<\/jats:styled-content> more accurately than did degree of anaemia. Special attention should be given to the female patients in the management of fatigue.<\/jats:p>","DOI":"10.1111\/bjh.13138","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T12:41:26Z","timestamp":1412167286000},"page":"361-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes"],"prefix":"10.1111","volume":"168","author":[{"given":"Fabio","family":"Efficace","sequence":"first","affiliation":[{"name":"Data Centre and Health Outcomes Research Unit Italian Group for Adult Haematological Diseases (GIMEMA) Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Translational Medicine Amedeo Avogadro University of Eastern Piedmont Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Breccia","sequence":"additional","affiliation":[{"name":"Department of Haematology University of Rome \u201cLa Sapienza\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Criscuolo","sequence":"additional","affiliation":[{"name":"Department of Haematology University of Rome \u201cCattolica S. 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