{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:09:23Z","timestamp":1789578563491,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Japanese Ministry of Health, Labor, and Welfare"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Allogeneic haematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) is still considered to play an important role as a consolidation therapy for high\u2010risk infants with acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>). Here, we retrospectively analysed outcomes of <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> in infants with <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> based on nationwide registry data of the Japan Society for Haematopoietic Cell Transplantation. A total of 132 allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> for infant <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> with <jats:italic><jats:styled-content style=\"fixed-case\">KMT<\/jats:styled-content>2A (<jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content>)<\/jats:italic> gene rearrangements, which were performed in first complete remission (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>1), were analysed. The 5\u2010year overall survival rate after transplantation was 67\u00b74\u00a0\u00b1\u00a04\u00b75%). Although recent <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> (after 2004) had a trend toward better survival, no statistical correlation was observed between outcomes and each factor, including age at diagnosis, initial leucocyte count, cytogenetics, donor types or conditioning of <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. Myeloablative conditioning with total body irradiation did not provide a better survival (60\u00b77\u00a0\u00b1\u00a09\u00b72%) over that with busulfan (<jats:styled-content style=\"fixed-case\">BU<\/jats:styled-content>; 67\u00b78\u00a0\u00b1\u00a05\u00b77%). Two of the 28 patients treated with irradiation, but none of the 90 <jats:styled-content style=\"fixed-case\">BU<\/jats:styled-content>\u2010treated patients, developed a secondary malignant neoplasm. In conclusion, allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> using <jats:styled-content style=\"fixed-case\">BU<\/jats:styled-content> was a valuable option for infant <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> with <jats:italic><jats:styled-content style=\"fixed-case\">KMT<\/jats:styled-content>2A<\/jats:italic> rearrangements in <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>1.<\/jats:p>","DOI":"10.1111\/bjh.13174","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T05:33:43Z","timestamp":1412919223000},"page":"564-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Allogeneic haematopoietic stem cell transplantation for infant acute lymphoblastic leukaemia with <i><scp>KMT<\/scp>2A (<scp>MLL<\/scp>)<\/i> rearrangements: a retrospective study from the paediatric acute lymphoblastic leukaemia working group of the Japan Society for Haematopoietic Cell Transplantation"],"prefix":"10.1111","volume":"168","author":[{"given":"Motohiro","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Paediatrics The University of Tokyo Tokyo Japan"},{"name":"Department of Cell Therapy and Transplantation Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiichiro","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Haematology Oncology Hyogo Children's Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology Saitama Children's Medical Centre Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology Ibaraki Children's Hospital Mito Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Takita","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Department of Paediatrics National Kyushu Cancer Centre Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Yabe","sequence":"additional","affiliation":[{"name":"Department of Cell Transplantation and Regenerative Medicine Tokai University Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Goto","sequence":"additional","affiliation":[{"name":"Division of Haemato\u2010oncology\/Regeneration Medicine Kanagawa Children's Medical Centre Yokohama 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