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The toxic effects of circulating free haemoglobin, haem, and iron are becoming increasingly understood and include an increased risk of thrombotic complications. This review summarizes the epidemiological evidence for an association between haemolysis and thrombosis and explores potential underlying mechanisms. New insights into the role haem plays in inflammatory signalling and in generating neutrophil extracellular traps (<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s) may provide useful strategies for managing pathological states associated with severe haemolysis. A better understanding of the toxic effects of haemolysis will result in better therapies to prevent the side effect of thrombosis.<\/jats:p>","DOI":"10.1111\/bjh.13183","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T12:08:54Z","timestamp":1413202134000},"page":"175-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["New perspectives on the thrombotic complications of haemolysis"],"prefix":"10.1111","volume":"168","author":[{"given":"Camilla","family":"L'Acqua","sequence":"first","affiliation":[{"name":"Department of Medical\u2010Surgical Pathophysiology and Organ Transplantation Universit\u00e0 degli Studi di Milano Milan Italy"},{"name":"Columbia University Medical Center \u2013 New York Presbyterian Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldad","family":"Hod","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center \u2013 New York Presbyterian Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/9849"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102013\u2010201432"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(67)90168-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11369"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06740.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59770"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07323.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-03-0220"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252626999"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-495887"},{"key":"e_1_2_9_13_1","unstructured":"Bolton\u2010Maggs P.H.B.(Ed) Poles D. 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