{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:34:13Z","timestamp":1792056853121,"version":"4.4.0"},"reference-count":93,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:00:00Z","timestamp":1413331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Primary Sj\u00f6gren Syndrome (\n                    <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content>\n                    ) is an autoimmune disease associated with an increased risk of lymphoma. Lymphomas complicating\n                    <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content>\n                    are mostly low\u2010grade B cell non\u2010Hodgkin lymphomas, predominantly of marginal zone histological type. Mucosal localization is predominant, notably mucosa\u2010associated lymphoid tissue lymphomas. Lymphomas often develop in organs where\n                    <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content>\n                    is active, such as salivary glands. Germinal centre (GC)\u2010like structures, high TNFSF13B (BAFF) and Flt3\u2010ligand (FLT3LG) levels and genetic impairment of\n                    <jats:italic>TNFAIP3<\/jats:italic>\n                    are new predictors of lymphoma development. These new findings allow a better understanding of the pathogenic mechanisms leading to lymphoma. We propose the following scenario: auto\u2010immune B cells with rheumatoid factor (RF) activity are continuously stimulated by immune complexes containing antibodies against more specific auto\u2010antigens, such as SSA\/Ro, SSB\/La or others. Germline abnormality of\n                    <jats:italic>TNFAIP3<\/jats:italic>\n                    leads to a decreased control of the NF\u2010\n                    <jats:styled-content style=\"fixed-case\">kB<\/jats:styled-content>\n                    pathway and thus promotes survival of B cells and oncogenic mutations especially in GC structure. Moreover, B cells are stimulated by a positive loop of activation induced by\n                    <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content>\n                    secretion. Thus, lymphomagenesis associated with\n                    <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content>\n                    exemplifies the development of antigen\u2010driven B\u2010cell lymphoma. The control of disease activity by a well\u2010targeted immunosuppressor is the primary objective of the management of the patient in order to repress chronic B cell stimulation.\n                  <\/jats:p>","DOI":"10.1111\/bjh.13192","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:55:03Z","timestamp":1413334503000},"page":"317-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":277,"title":["Sj\u00f6gren Syndrome\u2010associated lymphomas: an update on pathogenesis and management"],"prefix":"10.1111","volume":"168","author":[{"given":"Gaetane","family":"Nocturne","sequence":"first","affiliation":[{"name":"INSERM U1012 Paris\u2010Sud University Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[{"name":"INSERM U1012 Paris\u2010Sud University Le Kremlin\u2010Bic\u00eatre France"},{"name":"Department of Rheumatology Hopitaux Universitaires Paris\u2010Sud Paris\u2010Sud University Assistance Publique des Hopitaux de Paris Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203311434938"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei107"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111754"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200111)44:11<2633::AID-ART443>3.0.CO;2-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(96)80019-9"},{"key":"e_1_2_8_7_1","first-page":"e2010004","article-title":"Hepatitis C virus infection and lymphoma","volume":"2","author":"Bachy E.","year":"2010","journal-title":"Mediterranean Journal of Hematology and Infectious Diseases"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050068"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.036798"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.7.4929"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201216"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740310004676"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201381"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2466"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1561"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38726"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22458"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000715)87:2<211::AID-IJC9>3.0.CO;2-8"},{"key":"e_1_2_8_19_1","first-page":"588","article-title":"Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells","volume":"10","author":"Drexler H.G.","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190410001700989"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000081273"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-119974"},{"key":"e_1_2_8_23_1","first-page":"mdu365","article-title":"Autoimmune diseases associated with non\u2010Hodgkin lymphoma: a nationwide cohort study","author":"Fallah M.","year":"2014","journal-title":"Annals of Oncology"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2007.04.009"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1884"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059868"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013376"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10221"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1912"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200738013"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321194"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21887"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-6-888"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07969"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018472213872"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2007.02049.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/416603a"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2792"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90439-3"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni829"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.11.1697"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.1.97"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.1007"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.2.168"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200004)43:4<908::AID-ANR24>3.0.CO;2-K"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201351"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2010.64"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20205"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.04.005"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010014\u20103051\u2010x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-503383"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken246"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(99)00032-8"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.5.467"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1245"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3700"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110077"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102014\u2010205375"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes180"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260715"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202500"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204634"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.2.766"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61763-2"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21856"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11311"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303000"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.011"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23416"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110619"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.8.5676"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.10.006"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-011-0821-3"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.032094"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj004"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.04.006"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-1717-6"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-0873-03"},{"key":"e_1_2_8_79_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S.H.","year":"2008"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1466::AID-ANR21>3.0.CO;2-L"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22264"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.041186"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.144782"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27611"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.2.164"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390508"},{"key":"e_1_2_8_87_1","first-page":"2376","article-title":"Differential risk of non\u2010Hodgkin's lymphoma in Italian patients with primary Sjogren's syndrome","volume":"24","author":"Valesini G.","year":"1997","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199908)42:8<1765::AID-ANR28>3.0.CO;2-V"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.046193"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31824125e4"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200007)43:7<1647::AID-ANR31>3.0.CO;2-P"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200402"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.20.2337"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.6272"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.13192","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.13192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:25:03Z","timestamp":1696281903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.13192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,15]]},"references-count":93,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/bjh.13192"],"URL":"https:\/\/doi.org\/10.1111\/bjh.13192","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.722007866.793519357","asserted-by":"object"}]},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,15]]},"assertion":[{"value":"2014-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}