{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:24:55Z","timestamp":1760081095034,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T00:00:00Z","timestamp":1415232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1 ZIA HL006014-03"],"award-info":[{"award-number":["1 ZIA HL006014-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hydroxycarbamide therapy has been associated with significant oscillations in peripheral blood counts from myeloid, lymphoid and erythroid lineages in patients with polycythaemia vera and chronic myeloid leukaemia. We retrospectively evaluated serial blood counts over an 8\u2010year period from 44 adult patients with sickle cell disease receiving hydroxycarbamide. Platelet counts, leucocyte counts, haemoglobin values and reticulocyte counts, apportioned by hydroxycarbamide status, were analysed using a Lomb\u2010Scargle periodogram algorithm. Significant periodicities were present in one or more counts in 38 patients receiving hydroxycarbamide for a mean duration of 4\u00b781\u00a0years. Platelet and leucocyte counts oscillated in 56\u00b78% and 52\u00b73% of patients, respectively. These oscillations generally became detectable within days of initiating therapy. During hydroxycarbamide therapy, the predominant periods of oscillation were 27\u00a0\u00b1\u00a01\u00a0d for platelet counts and 15\u00a0\u00b1\u00a01\u00a0d for leucocyte counts. Despite an absolute decrease in leucocyte and platelet counts during hydroxycarbamide treatment, the amplitudes between nadirs and zeniths remained similar regardless of exposure. Our observations appear consistent with previously proposed models of cyclic haematopoiesis, and document that hydroxycarbamide\u2010induced oscillations in blood counts are innocuous phenomena not limited to myeloproliferative disorders as described previously. We speculate the known cell cycle inhibitory properties of hydroxycarbamide may accentuate otherwise latent constitutive oscillatory haematopoiesis.<\/jats:p>","DOI":"10.1111\/bjh.13203","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T05:35:22Z","timestamp":1415252122000},"page":"737-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oscillatory haematopoiesis in adults with sickle cell disease treated with hydroxycarbamide"],"prefix":"10.1111","volume":"168","author":[{"given":"John H.","family":"Baird","sequence":"first","affiliation":[{"name":"Hematology Branch National Heart Lung and Blood Institute Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina P.","family":"Minniti","sequence":"additional","affiliation":[{"name":"Hematology Branch National Heart Lung and Blood Institute Bethesda MD 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