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Despite its relatively low incidence and the fact that most cases of <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> resolve spontaneously, the cases that evolve to multi\u2010organ failure (<jats:styled-content style=\"fixed-case\">MOF<\/jats:styled-content>; severe <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>) have a mortality rate higher than 80% and represent one of the major clinical problems after <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>. For this reason, transplantation teams must have a pre\u2010established policy regarding preventive measures in high\u2010risk patients, strict daily control of weight and fluid balance during <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>, homogeneous diagnostic criteria, appropriate complementary studies for a correct differential diagnosis and measures to prevent and manage hepatorenal syndrome; in addition they must also be ready to start early treatment with defibrotide in patients with a possible severe <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>. Due to the lack of definitive evidence to enable the establishment of general recommendations in the management of <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>, this review analyses all of these aspects based on the author's personal experience.<\/jats:p>","DOI":"10.1111\/bjh.13215","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T09:48:42Z","timestamp":1416217722000},"page":"481-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":143,"title":["How <scp>I<\/scp> manage sinusoidal obstruction syndrome after haematopoietic cell transplantation"],"prefix":"10.1111","volume":"168","author":[{"given":"Enric","family":"Carreras","sequence":"first","affiliation":[{"name":"Haematology Department Hospital Clinic Barcelona Spain"},{"name":"Spanish Bone Marrow Donor Program Josep Carreras Foundation Barcelona Spain"},{"name":"Josep Carreras Leukaemia Research Institute 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