{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:31:34Z","timestamp":1788870694910,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Z-01-A1-000249-21"],"award-info":[{"award-number":["Z-01-A1-000249-21"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The diagnostic criteria for paediatric mastocytosis are largely based on adult studies and bone marrow findings are not well described in children. We evaluated use of the World Health Organization (\n                    <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>\n                    ) criteria for the diagnosis of systemic disease in paediatric mastocytosis. In addition, we identified unique clinico\u2010histopathological features within the biopsies. One hundred and thirteen children with paediatric mastocytosis were evaluated at the National Institutes of Health between 1986 and 2013. Complete bone marrow evaluations were performed in 50 cases. Seven children had repeat procedures. Bone marrows were analysed by histopathology, flow cytometry and for\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content>\n                    <\/jats:italic>\n                    D816V. Bone marrow biopsies displayed mild atypical haematopoietic maturation, increased haematogones and hypocellularity in a sub\u2010set of patients with urticaria pigmentosa, diffuse cutaneous mastocytosis and indolent systemic mastocytosis. Hypocellularity was most pronounced in those with urticaria pigmentosa. Haematogones were highest, on average, in patients with diffuse cutaneous mastocytosis or mastocytomas. There was no evidence of peripheral blood cytopenias, myelodysplastic syndrome, myeloproliferative neoplasm or leukaemia within this cohort. The\n                    <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>\n                    criteria are applicable for the diagnosis of systemic mastocytosis in paediatrics. Although unsuspected bone marrow findings typically seen in myeloproliferative disorders are frequent in paediatric mastocytosis, patients within this study remained clinically stable without progression to a more aggressive variant.\n                  <\/jats:p>","DOI":"10.1111\/bjh.13231","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T12:19:58Z","timestamp":1417177198000},"page":"865-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Abnormal bone marrow histopathology in paediatric mastocytosis"],"prefix":"10.1111","volume":"168","author":[{"given":"Melody C.","family":"Carter","sequence":"first","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases Laboratory of Allergic Diseases National Institutes of Health (NIH) Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean D.","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases Laboratory of Allergic Diseases National Institutes of Health (NIH) Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia S.","family":"Clark","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases Laboratory of Allergic Diseases National Institutes of Health (NIH) Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Wayne","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch Center for Cancer Research National Cancer Institute NIH Bethesda MD USA"},{"name":"Children's Center for Cancer and Blood Diseases Division of Hematology Oncology and Blood and Marrow Transplantation Children's Hospital Los Angeles Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Maric","sequence":"additional","affiliation":[{"name":"Hematology Section Department of Laboratory Medicine Clinical Center NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01696.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1994.tb00560.x"},{"key":"e_1_2_8_4_1","first-page":"320","article-title":"Pediatric cutaneous mastocytosis: a review of 180 patients","volume":"7","author":"Ben\u2010Amitai D.","year":"2005","journal-title":"The Israel Medical Association Journal"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.281"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01650.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12916"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01935.x"},{"key":"e_1_2_8_9_1","volume-title":"Bone Marrow Pathology: ASCP Integrative Hematopathology","author":"Foucar K.","year":"2010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.101761"},{"key":"e_1_2_8_11_1","first-page":"54","volume-title":"World Health Organization (WHO) Classification of Tumours. 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