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De\u2010escalation studies have shown that a reduced dose of 30\u00a0mg is as effective as 100\u00a0mg in preventing <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> in matched related donor (<jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>) transplants. Dose reduction in matched unrelated donor (<jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content>) transplants is feasible but the comparative efficacy of alemtuzumab in this setting is not known and opinions vary widely concerning the optimal level of <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> prophylaxis that should be achieved. Through retrospective analysis we made an objective comparison of <jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content> transplants receiving an empirically reduced dose of 60\u00a0mg, with <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> transplants receiving a 30\u00a0mg dose. We observed proportionate levels of alemtuzumab according to dose but an inverse relationship with body surface area particularly in <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> transplants. <jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content> transplants experienced more acute and chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>, higher T cell chimerism, more sustained use of ciclosporin and less need for donor lymphocyte infusion than <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> transplants. Thus, doubling the dose of alemtuzumab to 60\u00a0mg did not provide equivalent prevention of <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content> transplant although there was no difference in non\u2010relapse mortality or survival compared with <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> transplants.<\/jats:p>","DOI":"10.1111\/bjh.13239","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T22:00:46Z","timestamp":1422568846000},"page":"874-881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A comparative study of reduced dose alemtuzumab in matched unrelated donor and related donor reduced intensity transplants"],"prefix":"10.1111","volume":"168","author":[{"given":"Laura","family":"Jardine","sequence":"first","affiliation":[{"name":"Institute of Cellular Medicine 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