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Here, we report on the treatment and follow\u2010up of ten patients diagnosed with relapsed or refractory mature B\u2010cell Non Hodgkin Lymphoma (B\u2010<jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>), Burkitt leukaemia (B\u2010<jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content>) or pre B\u2010acute lymphoblastic leukaemia (pre B\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>). All children were treated with <jats:styled-content style=\"fixed-case\">FBTA<\/jats:styled-content>05 (now designated Lymphomun), an anti\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3 x anti\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 trifunctional bispecific antibody (trAb) in compassionate use. Within individual treatment schedules, Lymphomun was applied (a) after allogeneic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a06) to induce sustained long\u2010term remission, or (b) stand alone prior to subsequent chemotherapy to eradicate residual disease before allo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). Nine of ten children displayed a clinical response: three stable diseases (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>), one partial remission (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) and five induced or sustained complete remissions (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>). Five of these nine responders died during follow\u2010up. The other patients still maintain <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> with a current overall survival of 874\u20131424\u00a0days (median: 1150\u00a0days). In conclusion, despite the dismal clinical prognosis of children refractory to standard therapy, immunotherapy with Lymphomun resulted in a favourable clinical outcome in this cohort of refractory paediatric patients.<\/jats:p>","DOI":"10.1111\/bjh.13242","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T11:39:16Z","timestamp":1418297956000},"page":"90-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Immunotherapy with the trifunctional anti\u2010<scp>CD<\/scp>20 x anti\u2010<scp>CD<\/scp>3 antibody <scp>FBTA<\/scp>05 (Lymphomun) in paediatric high\u2010risk patients with recurrent <scp>CD<\/scp>20\u2010positive B cell malignancies"],"prefix":"10.1111","volume":"169","author":[{"given":"Friedhelm R.","family":"Schuster","sequence":"first","affiliation":[{"name":"Department of Paediatric Oncology Haematology and Immunology University of Duesseldorf Duesseldorf 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