{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:55:47Z","timestamp":1790607347478,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T00:00:00Z","timestamp":1418860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000380","name":"Guy's and St Thomas' Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We describe the findings from a national study of maternal and fetal outcomes of pregnancy in women with sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>). Data were collected via the <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nited <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ingdom <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>bstetric <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>urveillance <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ystem between 1 <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 2010 and 31 <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2011 from 109 women, of whom 51 (46\u00b78%) had <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> and 44 (40\u00b74%) had <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>. Data included antenatal, maternal and fetal outcomes. Comparisons were made between women with <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>. Incidence of complications were acute pain (57%), blood transfusion (26%), urinary tract infection (<jats:styled-content style=\"fixed-case\">UTI<\/jats:styled-content>; 12%) and critical care unit admission (23%) and these were all more common in women with Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> than Hb<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>. There was no difference in the incidence of acute chest syndrome, hypertension and venous thromboembolism between Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> and Hb<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>. Women with Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> were more likely to deliver at &lt;37\u00a0weeks gestation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701) and their babies were more likely to have reduced birth weight. Delivery at &lt;34\u00a0weeks was increased in both Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> and Hb<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> women (5\u00b79% vs. 4\u00b76%) compared to national data. This study confirms a high rate of maternal and fetal complications in mothers with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>, even in women with Hb<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>, which has previously been considered to have a more benign phenotype in pregnancy.<\/jats:p>","DOI":"10.1111\/bjh.13270","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:50:16Z","timestamp":1418971816000},"page":"129-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Pregnancy outcome in patients with sickle cell disease in the <scp>UK<\/scp> \u2013 a national cohort study comparing sickle cell anaemia (<scp>H<\/scp>b<scp>SS<\/scp>) with <scp>H<\/scp>b<scp>SC<\/scp> disease"],"prefix":"10.1111","volume":"169","author":[{"given":"Eugene","family":"Oteng\u2010Ntim","sequence":"first","affiliation":[{"name":"King's College London London UK"},{"name":"Directorate of Women's Health Guy's and St Thomas' Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ayensah","sequence":"additional","affiliation":[{"name":"Directorate of Women's Health Guy's and St Thomas' Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Knight","sequence":"additional","affiliation":[{"name":"Perinatal Epidemiology Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610802667112"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1119-3077.127441"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1002-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2013.780249"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443619109007771"},{"key":"e_1_2_7_7_1","first-page":"375","article-title":"Prevention and control of haemoglobinopathies","volume":"73","author":"Angastiniotis M.","year":"1995","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026281"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.12.020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000308710.86880.a6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1258\/om.2010.100026"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92633-6"},{"key":"e_1_2_7_13_1","volume-title":"Perinatal Mortality 2009","author":"CMACE","year":"2011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.09.017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-10-200511150-00006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21735"},{"key":"e_1_2_7_17_1","unstructured":"Hospital Episode Statistics.NHS Maternity Statistics 2008\u20132009. (Tables 26\u201329).www.hscic.gov.uk\/catalogue\/PUB01705\/nhs-mate-2008-2009-tab.xls."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb10900.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00609.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198812013192204"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.2920060411"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.05.022"},{"key":"e_1_2_7_23_1","volume-title":"Hypertension in Pregnancy: The Management of Hypertensive Disorders During Pregnancy","author":"NICE","year":"2010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61229-X"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107043250103"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.02.007"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07330-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000127433.23611.54"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00678.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00367-3"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.058859"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115477"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10937"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2768"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1983.tb08893.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.016"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7079.492"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04132-5"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.11-0625"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610903003175"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.13270","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.13270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:51:58Z","timestamp":1696341118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.13270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,18]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/bjh.13270"],"URL":"https:\/\/doi.org\/10.1111\/bjh.13270","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,18]]},"assertion":[{"value":"2014-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}