{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:19:25Z","timestamp":1761513565428,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T00:00:00Z","timestamp":1418947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001921","name":"Public Health Research Programme","doi-asserted-by":"publisher","award":["2003"],"award-info":[{"award-number":["2003"]}],"id":[{"id":"10.13039\/501100001921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Relapse after transplantation is a major cause of treatment failure in paediatric acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>). Here, we report the findings of a prospective national study designed to investigate the feasibility of immune intervention in children in first or subsequent remission following myeloablative conditioning. This study included 133 children who received a transplant for <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> between 2005 and 2008. Minimal Residual Disease (<jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>) based on T cell receptor\/immunoglobulin gene rearrangements was measured on days \u221230, 30, 90 and 150 post\u2010transplantation. Ciclosporin treatment was rapidly discontinued and donor lymphocyte infusions (<jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content>) were programmed for patients with a pre\u2010 or post\u2010transplant <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> status \u226510<jats:sup>\u22123<\/jats:sup>. Only nine patients received <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content>. Pre\u2010 and post\u2010transplant <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> status, and the duration of ciclosporin were independently associated with 5\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>), which was 62\u00b707% for the whole cohort. <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was substantially higher in patients cleared of <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> than in those with persistent <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> (52\u00b73% vs. 14\u00b73%, respectively). Only pre\u2010transplant <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> status (Hazard Ratio 2\u00b757, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704) and duration of ciclosporin treatment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) were independently associated with relapse. The kinetics of chimerism were not useful for predicting relapse, whereas <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> monitoring up to 90\u00a0d post\u2010transplantation was a valuable prognostic tool to guide therapeutic intervention.<\/jats:p>","DOI":"10.1111\/bjh.13272","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:53:23Z","timestamp":1418986403000},"page":"249-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Follow\u2010up of post\u2010transplant minimal residual disease and chimerism in childhood lymphoblastic leukaemia: 90\u00a0d to react"],"prefix":"10.1111","volume":"169","author":[{"given":"C\u00e9cile","family":"Pochon","sequence":"first","affiliation":[{"name":"Department of Paediatric Haematology\/oncology University Hospital of Nancy Nancy 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