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These aims were pursued through risk\u2010directed stratification based on presenting clinical and genetic features, minimal residual disease (<jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>) levels and treatment response. All the patients achieved completed remission with 5\u2010year event\u2010free survivals of 82\u00b76\u00a0\u00b1\u00a09\u00b77% (low risk), 52\u00b76\u00a0\u00b1\u00a08\u00b74% (intermediate risk), 28\u00b76\u00a0\u00b1\u00a017\u00b71% (high risk). Disease recurrence was detected in bone marrow, bone marrow plus testis, testis alone and central nervous system in 16 (24\u00b72%), 1 (1\u00b75%), 1 (1\u00b75%) and 1 (1\u00b75%) patients respectively. No deaths were reported during induction. The <jats:styled-content style=\"fixed-case\">SCMC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\u20102005 trial for <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> patients &lt;2\u00a0years old indicated high remission induction and low infection and treatment\u2010related mortality rates.<\/jats:p>","DOI":"10.1111\/bjh.13288","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T22:27:31Z","timestamp":1423175251000},"page":"267-277","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Treatment outcome of young children with acute lymphoblastic leukaemia: achievements and directions implied from Shanghai Children's Medical Centre based <scp>SCMC<\/scp>\u2010<scp>ALL<\/scp>\u20102005 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