{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:08:42Z","timestamp":1791223722817,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HA6145\/1-2"],"award-info":[{"award-number":["HA6145\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Nodular lymphocyte predominant Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content>) and T cell\/histiocyte rich large B cell lymphoma (<jats:styled-content style=\"fixed-case\">THRLBCL<\/jats:styled-content>) usually affect middle\u2010aged men, show tumour cells with a B cell phenotype and a low tumour cell content. Whereas the clinical behaviour of <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content> is indolent, <jats:styled-content style=\"fixed-case\">THRLBCL<\/jats:styled-content> presents with advanced stage disease and an aggressive behaviour. In the present study, array comparative genomic hybridization was performed in seven typical <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content>, four <jats:styled-content style=\"fixed-case\">THRLBCL<\/jats:styled-content>\u2010like <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content> variants, six <jats:styled-content style=\"fixed-case\">THRLBCL<\/jats:styled-content> and four diffuse large B cell lymphomas (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) derived from <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content>. The number of genomic aberrations was higher in <jats:styled-content style=\"fixed-case\">THRLBCL<\/jats:styled-content> compared with typical and <jats:styled-content style=\"fixed-case\">THRLBCL<\/jats:styled-content>\u2010like variant of <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content>. Gains of 2p16.1 and losses of 2p11.2 and 9p11.2 were commonly observed in typical and <jats:styled-content style=\"fixed-case\">THRLBCL<\/jats:styled-content>\u2010like variants of <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content> as well as <jats:styled-content style=\"fixed-case\">THRLBCL<\/jats:styled-content>. Gains of 2p16.1, affecting the <jats:italic><jats:styled-content style=\"fixed-case\">REL<\/jats:styled-content><\/jats:italic> locus were confirmed in an independent cohort. Expression of the <jats:styled-content style=\"fixed-case\">REL<\/jats:styled-content> protein was observed at similar frequencies in typical and <jats:styled-content style=\"fixed-case\">THRLBCL<\/jats:styled-content>\u2010like variant of <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content> as well as <jats:styled-content style=\"fixed-case\">THRLBCL<\/jats:styled-content> (33\u201338%). In conclusion, the present study reveals further similarities between <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">THRLBCL<\/jats:styled-content> on the genomic level, confirming that\u00a0these entities are part of a pathobiological spectrum with common molecular features, but varying clinical presentations.<\/jats:p>","DOI":"10.1111\/bjh.13310","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T21:17:48Z","timestamp":1422911868000},"page":"415-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Array comparative genomic hybridization reveals similarities between nodular lymphocyte predominant Hodgkin lymphoma and T cell\/histiocyte rich large B cell lymphoma"],"prefix":"10.1111","volume":"169","author":[{"given":"Sylvia","family":"Hartmann","sequence":"first","affiliation":[{"name":"Dr. Senckenberg 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