{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:33:21Z","timestamp":1787866401027,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"H. Kopps Foundation"},{"name":"Hasselbalch & Lykkegaard Andersen Foundation"},{"name":"Kong Christian den Tiendes Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Watch and wait (<jats:styled-content style=\"fixed-case\">WAW<\/jats:styled-content>) is a common approach for asymptomatic, advanced stage follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>), but single\u2010agent rituximab is an alternative for these patients. In this nationwide study we describe the outcome of patients selected for <jats:styled-content style=\"fixed-case\">WAW<\/jats:styled-content>. A cohort of 286 out of 849 (34%) stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IVA FL<\/jats:styled-content> patients seen between 2000 and 2011, were managed expectantly and included. The 5\u2010year progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) was 35% [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 29\u201342]. The 10\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was 65% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 54\u201378), and the cumulative risk of dying from lymphoma within 10\u00a0years of diagnosis was 13% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 7\u201320). Elevated lactate dehydrogenase and &gt; four nodal regions involved were associated with a higher risk of lymphoma treatment and death from lymphoma. The <jats:styled-content style=\"fixed-case\">WAW<\/jats:styled-content> patients and a matched background population had similar <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> during the first 50\u00a0months after diagnosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b77), but <jats:styled-content style=\"fixed-case\">WAW<\/jats:styled-content> patients had increased risk of death after 50\u00a0months (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). The estimated loss of residual life after 10\u00a0years was 6\u00b78\u00a0months. The 10\u2010year cumulative risk of histological transformation was 22% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 15\u201329) and the 3\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> after transformation was 71% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 58\u201387%). In conclusion, advanced stage <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> managed by <jats:styled-content style=\"fixed-case\">WAW<\/jats:styled-content> had a favourable outcome and abandoning this strategy could lead to overtreatment in some patients.<\/jats:p>","DOI":"10.1111\/bjh.13316","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:35:56Z","timestamp":1424738156000},"page":"435-444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["A population\u2010based study of prognosis in advanced stage follicular lymphoma managed by watch and wait"],"prefix":"10.1111","volume":"169","author":[{"given":"Tarec Christoffer","family":"El\u2010Galaly","sequence":"first","affiliation":[{"name":"Department of Haematology Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"},{"name":"Clinical 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