{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:45:05Z","timestamp":1791305105811,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Kyowa Hakko Kirin Co., Ltd.,","award":["none"],"award-info":[{"award-number":["none"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This multicentre, randomized, phase\n                    <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                    study was conducted to examine whether the addition of mogamulizumab, a humanized anti\u2010\n                    <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\n                    chemokine receptor 4 antibody, to\n                    <jats:styled-content style=\"fixed-case\">mLSG<\/jats:styled-content>\n                    15, a dose\u2010intensified chemotherapy, further increases efficacy without compromising safety of patients with newly diagnosed aggressive adult T\u2010cell leukaemia\u2010lymphoma (\n                    <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>\n                    ). Patients were assigned 1:1 to receive\n                    <jats:styled-content style=\"fixed-case\">mLSG<\/jats:styled-content>\n                    15 plus mogamulizumab or\n                    <jats:styled-content style=\"fixed-case\">mLSG<\/jats:styled-content>\n                    15 alone. The primary endpoint was the complete response rate (%\n                    <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>\n                    ); secondary endpoints included the overall response rate (\n                    <jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>\n                    ) and safety. The %\n                    <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>\n                    in the\n                    <jats:styled-content style=\"fixed-case\">mLSG<\/jats:styled-content>\n                    15\u2010plus\u2010mogamulizumab arm (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a029) were 52% [95% confidence interval (\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ), 33\u201371%] and 86%, respectively; the corresponding values in the\n                    <jats:styled-content style=\"fixed-case\">mLSG<\/jats:styled-content>\n                    15 arm (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a024) were 33% (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    , 16\u201355%) and 75%, respectively. Grade\u00a0\u2265\u00a03 treatment\u2010emergent adverse events, including anaemia, thrombocytopenia, lymphopenia, leucopenia and decreased appetite, were observed more frequently (\u226510% difference) in the\n                    <jats:styled-content style=\"fixed-case\">mLSG<\/jats:styled-content>\n                    15\u2010plus\u2010mogamulizumab arm. Several adverse events, including skin disorders, cytomegalovirus infection, pyrexia, hyperglycaemia and interstitial lung disease, were observed only in the\n                    <jats:styled-content style=\"fixed-case\">mLSG<\/jats:styled-content>\n                    15\u2010plus\u2010mogamulizumab arm. Although the combination strategy showed a potentially less favourable safety profile, a higher %\n                    <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>\n                    was achieved, providing the basis for further investigation of this novel treatment for newly diagnosed aggressive\n                    <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>\n                    . This study was registered at ClinicalTrials.gov, identifier: NCT01173887.\n                  <\/jats:p>","DOI":"10.1111\/bjh.13338","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T14:15:46Z","timestamp":1425305746000},"page":"672-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":252,"title":["Dose\u2010intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T\u2010cell leukaemia\u2010lymphoma: a randomized phase\n                    <scp>II<\/scp>\n                    study"],"prefix":"10.1111","volume":"169","author":[{"given":"Takashi","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Haematology and Oncology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuro","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Haematology Japanese Red Cross Nagasaki Genbaku Hospital Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Haematology and Institute for Clinical Research National Hospital Organization Kumamoto Medical Centre Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Suzushima","sequence":"additional","affiliation":[{"name":"Department of Haematology Kumamoto Shinto General Hospital Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiharu","family":"Uozumi","sequence":"additional","affiliation":[{"name":"Department of Haematology and Immunology Kagoshima University Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhito","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Haematology and Cell Therapy Aichi Cancer Centre Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naokuni","family":"Uike","sequence":"additional","affiliation":[{"name":"Department of Haematology National Hospital Organization Kyushu Cancer Centre Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Saburi","sequence":"additional","affiliation":[{"name":"Department of Haematology Oita Prefectural Hospital Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisato","family":"Nosaka","sequence":"additional","affiliation":[{"name":"Cancer Centre Kumamoto University Hospital Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atae","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Haematology Imamura Bun\u2010in Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensei","family":"Tobinai","sequence":"additional","affiliation":[{"name":"Department of Haematology National Cancer Centre Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Bioregulatory Medicine Ehime University Graduate School of Medicine Toon Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ishitsuka","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Haematology, and Infectious Diseases Department of Internal Medicine Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Haematology National Hospital Organization Nagasaki Medical Centre Ohmura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Taira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Heartlife Hospital Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiyoshi","family":"Moriuchi","sequence":"additional","affiliation":[{"name":"Department of Haematology Sasebo City General Hospital Sasebo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Imada","sequence":"additional","affiliation":[{"name":"Department of Haematology Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Akinaga","sequence":"additional","affiliation":[{"name":"Kyowa Hakko Kirin Co., Ltd. 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