{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:19:15Z","timestamp":1790543955290,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chong Hin Loon Memorial Cancer and Biotherapy Research Cancer, National Yang-Ming University"},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V104C-182"],"award-info":[{"award-number":["V104C-182"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009096","name":"Taiwan Clinical Oncology Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009096","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Pericardial effusion (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>) is a rare but potentially life\u2010threatening complication for allogeneic haematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) recipients. The risk factors, aetiology, incidence and therapy are largely unclear. To investigate this issue, we reviewed 391 adult patients undergoing allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> between January 2003 and December 2013. Twelve out of 391 patients (3\u00b71%) developed <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> of moderate to large amounts, including 9 out of 12 patients (75%) identified as late\u2010onset <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>. Two out of the nine patients with late\u2010onset <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> experienced recurrent effusion. The median age at <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> was 44\u00b75\u00a0years (range: 22\u201363\u00a0years) among the 12 patients with <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> and 47\u00a0years in the late\u2010onset patients. Multivariate analysis revealed that multiple transplant procedures was a significant risk factor for <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7036) and a trend as risk factor in patients aged&gt;50\u00a0years (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7066). For late\u2010onset <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>, pre\u2010transplant age&gt;50\u00a0years (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7032) and extensive chronic graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">cGVHD<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7006) remained statistically significant on multivariate analysis. Currently, there are no published data exploring the risk factors for post\u2010transplant <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> in adult patients of allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. Our study determined the risk factors and incidence for the post\u2010transplant <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>, especially in the late\u2010onset group.<\/jats:p>","DOI":"10.1111\/bjh.13357","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T22:13:39Z","timestamp":1427494419000},"page":"737-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Risk factors for pericardial effusion in adult patients receiving allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"169","author":[{"given":"Yao\u2010Chung","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medicine of Yang\u2010Ming Branch Taipei City Hospital Taipei Taiwan"},{"name":"Division of Haematology and Oncology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Hsuan","family":"Chien","sequence":"additional","affiliation":[{"name":"Division of Haematology and Oncology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai\u2010Wen","family":"Fan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Ophthalmology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hung","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Haematology and Oncology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Medicine Cardinal Tien Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh\u2010Pyng","family":"Gau","sequence":"additional","affiliation":[{"name":"Division of Haematology and Oncology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Jen","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Haematology and Oncology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Bin","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Haematology and Oncology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Haematology and Oncology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang\u2010Tsai","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Division of Haematology and Oncology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Hwang","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Haematology and Oncology Department of Medicine Taipei Veterans General Hospital Taipei 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