{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:10:50Z","timestamp":1790543450944,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T00:00:00Z","timestamp":1427673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing Natural Science Foundation, China","award":["No.7143183"],"award-info":[{"award-number":["No.7143183"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study retrospectively collected the clinical and laboratory data of 114 patients with Castleman disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) from a single medical centre. Clinical classification identified 62 patients (54\u00b74%) with unicentric Castleman disease and 52 (45\u00b76%) with multi\u2010centric Castleman disease. Pathological classification revealed 68 cases (59\u00b76%) of hyaline vascular variant, 16 (14\u00b71%) mixed cellular variant (Mix) and 30 (26\u00b73%) plasmacytic variant. Clinical complications occurred in 69 <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients, including 37 cases of paraneoplastic pemphigus (<jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>) and 25 cases with renal complications. Haematological involvement, pleural effusion and\/or ascites and <jats:styled-content style=\"fixed-case\">POEMS<\/jats:styled-content> syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) were also found. Univariate analysis showed that presence of clinical complications and <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> were both risk factors relating to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patient survival. Prognostic factors showing <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b715 in univariate analysis and those with clinical significance were subjected to multivariate analysis using a Cox regression model. <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> presence and age over 40\u00a0years both significantly adversely affected survival. Thus, only presence of <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> was identified as an independent unfavourable survival risk factor in both univariate and multivariate analyses. Overall, the present data provide a panoramic description of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> cases and emphasize that the presence of <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> is an adverse prognostic factor.<\/jats:p>","DOI":"10.1111\/bjh.13378","type":"journal-article","created":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T08:52:36Z","timestamp":1427705556000},"page":"834-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Clinical and laboratory characterization of 114 cases of Castleman disease patients from a single centre: paraneoplastic pemphigus is an unfavourable prognostic factor"],"prefix":"10.1111","volume":"169","author":[{"given":"Yujun","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Haematology Peking University First Hospital Beijing 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