{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:38:20Z","timestamp":1790113100034,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T00:00:00Z","timestamp":1428364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Data from the National LymphoCare Study (a prospective, multicentre registry that enrolled follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) patients from 2004 to 2007) were used to determine disease characteristics, treatment patterns, outcomes and prognosis for elderly <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">eFL<\/jats:styled-content>) patients. Of 2650 <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients, 209 (8%) were aged &gt;80\u00a0years; these <jats:styled-content style=\"fixed-case\">eFL<\/jats:styled-content> patients more commonly had grade 3 disease, less frequently received chemoimmunotherapy and anthracyclines, and had lower response rates when compared to younger patients. With a median follow\u2010up of 6.9\u00a0years, 5\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">eFL<\/jats:styled-content> patients was 59%; 38% of deaths were lymphoma\u2010related. No treatment produced superior <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> among <jats:styled-content style=\"fixed-case\">eFL<\/jats:styled-content> patients. In multivariate Cox models, anaemia, B\u2010symptoms and male sex predicted worse <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b701); a prognostic index of these factors (0, 1 or \u22652 present) predicted <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> [hazard ratio (95% CI): \u22652 vs. 0, 4\u00b772 (2\u00b738\u20139\u00b733); 1 vs. 0, 2\u00b763 (1\u00b739\u20134\u00b798)], with a higher concordance index (0\u00b763) versus the Follicular Lymphoma International Prognostic Index (0\u00b755). The index was validated in an independent cohort. In the largest prospective <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\u2010based <jats:styled-content style=\"fixed-case\">eFL<\/jats:styled-content> cohort, no optimal therapy was identified and nearly 40% of deaths were lymphoma\u2010related, representing baseline outcomes in the modern era.<\/jats:p>","DOI":"10.1111\/bjh.13399","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T04:49:24Z","timestamp":1428468564000},"page":"85-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Disease characteristics, treatment patterns, prognosis, outcomes and lymphoma\u2010related mortality in elderly follicular lymphoma in the United States"],"prefix":"10.1111","volume":"170","author":[{"given":"Chadi","family":"Nabhan","sequence":"first","affiliation":[{"name":"Department of Medicine Section of Hematology and Oncology The University of Chicago Comprehensive Cancer 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