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Here we report data in all patients treated on the National Cancer Institute 1312 trial, demonstrating long\u2010term disease control and the ability to retreat patients relapsing off\u2010therapy. In all, 84 patients with <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> and 47 with <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> were enrolled. Responses occurred early, were clinically meaningful and of very long duration in some cases. Notably, patients with <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> receiving romidepsin as third\u2010line therapy or later had a comparable response rate (32%) of similar duration as the total population (38%). Eight patients had treatment breaks of 3\u00b75\u00a0months to 10\u00a0years; in four of six patients, re\u2010initiation of treatment led to clear benefit. Safety data show slightly greater haematological and constitutional toxicity in <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">cDNA<\/jats:styled-content> microarray studies show unique individual gene expression profiles, minimal overlap between patients, and both induction and repression of gene expression that reversed within 24\u00a0h. These data argue against cell death occurring as a result of an epigenetics\u2010mediated gene induction programme. Together this work supports the safety and activity of romidepsin in T\u2010cell lymphoma, but suggests a complex mechanism of action.<\/jats:p>","DOI":"10.1111\/bjh.13400","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T03:58:57Z","timestamp":1429502337000},"page":"96-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Romidepsin in peripheral and cutaneous T\u2010cell lymphoma: mechanistic implications from clinical and correlative data"],"prefix":"10.1111","volume":"170","author":[{"given":"Susan E.","family":"Bates","sequence":"first","affiliation":[{"name":"Developmental Therapeutics Branch NCI NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Eisch","sequence":"additional","affiliation":[{"name":"Developmental Therapeutics Branch NCI NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Radiology Warren G Magnuson Clinical Center NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Rosing","sequence":"additional","affiliation":[{"name":"Consultative Cardiology NHLBI NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Turner","sequence":"additional","affiliation":[{"name":"Dermatology Branch NCI Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Pittaluga","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology CCR NCI Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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