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The addition of non\u2010vitamin K antagonist oral anticoagulants (<jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content>s) to the pharmacopoeia represents the first of a number of recent advancements in the management of <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>. Worldwide, uptake of these agents has been avid, although drug selection, reversal and chronic treatment effects continue to be controversial areas. Multi\u2010centre studies to evaluate the impact of <jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content>s on long\u2010term outcomes, including thrombosis recurrence and post\u2010thrombotic syndrome (<jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content>), are ongoing. Validation of tools capable of predicting <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> would enable patient selection for early aggressive intervention, such as local thrombolysis. 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