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Minimal residual disease (<jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>) was assessed by real\u2010time polymerase chain reaction at the end of induction (<jats:styled-content style=\"fixed-case\">EOI<\/jats:styled-content>) and consolidation (<jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content>). Seventy per cent (7\/10) and 71% (5\/7) were <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>\u2010positive at <jats:styled-content style=\"fixed-case\">EOI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content>, respectively, with no disease recurrences. <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> after induction and consolidation did not predict relapse and subsequent therapy appeared to eliminate <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>. Thus, assessing <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> at a later time point is warranted in future trials to determine its clinical significance.<\/jats:p>","DOI":"10.1111\/bjh.13443","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T04:14:56Z","timestamp":1428552896000},"page":"367-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of persistent minimal residual disease post\u2010consolidation therapy in children and adolescents with advanced Burkitt leukaemia: a Children's Oncology Group Pilot Study Report"],"prefix":"10.1111","volume":"170","author":[{"given":"Bruce","family":"Shiramizu","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology University of Hawaii Honolulu HI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanton","family":"Goldman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Medical City Children's Hospital Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Nebraska College of Public Health Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Agsalda\u2010Garcia","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology University of Hawaii Honolulu HI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Galardy","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Mayo Clinic Rochester MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherrie L.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Kimble","family":"Frazer","sequence":"additional","affiliation":[{"name":"Section of Pediatric Hematology\u2010Oncology University of Oklahoma Health Sciences Center Oklahoma City OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren","family":"Sanger","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Nebraska College of Public Health Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Gross","sequence":"additional","affiliation":[{"name":"Center for Global Health NCI NIH DHHS Rockville MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Pediatrics New York Medical College Valhalla NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Barth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Mussolin","sequence":"additional","affiliation":[{"name":"Istituto di Ricerca Pediatrico\u2010Fondazione Citt\u00e0 della Speranza\u2010University of Padua Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell S.","family":"Cairo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics New York Medical College Valhalla NY USA"},{"name":"Department of Medicine New York Medical College Valhalla NY USA"},{"name":"Department of Pathology New York Medical College Valhalla NY USA"},{"name":"Department of Microbiology &amp; Immunology New York Medical College Valhalla NY USA"},{"name":"Department of Cell Biology &amp; Anatomy New York Medical College Valhalla NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/412163"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-036665"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.3369"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.255"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13040"},{"key":"e_1_2_8_7_1","first-page":"332","article-title":"Classification, staging and end results of treatment of childhood non\u2010Hodgkin's lymphomas: dissimilarities from lymphomas in adults","volume":"7","author":"Murphy S.B.","year":"1980","journal-title":"Seminars in Oncology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.3159"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.8161"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08681.x"},{"volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2008","author":"Swerdlow S.H.","key":"e_1_2_8_11_1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0973"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.13443","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.13443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T01:06:36Z","timestamp":1696035996000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.13443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,8]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/bjh.13443"],"URL":"https:\/\/doi.org\/10.1111\/bjh.13443","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"type":"print","value":"0007-1048"},{"type":"electronic","value":"1365-2141"}],"subject":[],"published":{"date-parts":[[2015,4,8]]},"assertion":[{"value":"2014-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}