{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:57Z","timestamp":1740126177036,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) in young adults (<jats:styled-content style=\"fixed-case\">YA<\/jats:styled-content>, &lt;40\u00a0years old) is uncommon, and the clinical characteristics and outcomes of this group are not well defined. We conducted a retrospective database review of 427 patients with newly diagnosed <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> aged 65\u00a0years or less registered at Princess Margaret Cancer Centre between 1995 and 2010. <jats:styled-content style=\"fixed-case\">YA<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a061) and those 40\u201365 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0366) were compared with regards to clinical stage at diagnosis, <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> International Prognostic Index (<jats:styled-content style=\"fixed-case\">FLIPI<\/jats:styled-content>) score, and the following clinical outcomes: time to second treatment, cause\u2010specific survival (CSS) and overall survival (OS). At diagnosis, stage and <jats:styled-content style=\"fixed-case\">FLIPI<\/jats:styled-content> score were similar, as were the proportion of patients requiring therapy (<jats:styled-content style=\"fixed-case\">YA<\/jats:styled-content> 75% <jats:italic>versus<\/jats:italic> older adults 71%). Median follow\u2010up was 8\u00b71\u00a0years. Time to second therapy was similar in both age groups (5\u2010year probability 23% <jats:styled-content style=\"fixed-case\">YA <\/jats:styled-content><jats:italic>versus<\/jats:italic> 27% older adults; Gray's <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00\u00b776). Ten\u2010year OS was significantly higher for <jats:styled-content style=\"fixed-case\">YA<\/jats:styled-content> (87% <jats:italic>versus<\/jats:italic> older adults 72%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7029). On multivariate analysis, age &lt;40\u00a0years, low <jats:styled-content style=\"fixed-case\">FLIPI<\/jats:styled-content> score and observation as initial management were favourable prognostic factors for OS and CSS. We conclude that <jats:styled-content style=\"fixed-case\">YA<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> have a favourable prognosis compared to older patients; whether this reflects competing mortality risks or age\u2010related differences in lymphoma biology warrants further investigation.<\/jats:p>","DOI":"10.1111\/bjh.13451","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T05:13:25Z","timestamp":1429766005000},"page":"384-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical characteristics and early treatment outcomes of follicular lymphoma in young adults"],"prefix":"10.1111","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1022-9899","authenticated-orcid":false,"given":"Shane A.","family":"Gangatharan","sequence":"first","affiliation":[{"name":"Division of Medical Oncology and Haematology 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