{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:39:01Z","timestamp":1779208741269,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Imatinib mesylate (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>) is used for the management of childhood chronic myeloid leukaemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>). The most effective dosage of <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> and its long\u2010term efficacy in children are not well defined. The purpose of this multicentre study is to report on the long\u2010term results of high\u2010dose <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> (340\u00a0mg\/m<jats:sup>2<\/jats:sup>\/d) in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients in chronic phase (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>) aged &lt;18\u00a0years at diagnosis. A total of 47 <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients with a median age at diagnosis of 11\u00a0years 9\u00a0months were enrolled in nine Italian centres. Complete cytogenetic response was achieved in 91\u00b75% of the evaluable patients at a median time of 6\u00a0months. <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> International Scale\u00a0\u2264\u00a00\u00b71% (major molecular response; <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content>) and \u22640\u00b701% (molecular response; <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) at 12\u00a0months were 66\u00b76% and 33%, respectively. During follow\u2010up, <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> were achieved in 78\u00b76% and 61% of children, respectively. <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> was safely discontinued in 3 long\u2010term treated children with a durable <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>. Twelve patients (eight cytogenetic\/molecular responders) underwent stem cell transplantation. The progression\u2010free survival probabilities at 96\u00a0months for responding patients who continued <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> and for those transplanted were 60% and 50%, respectively. After a median follow\u2010up of 52\u00a0months (range 3\u2013146), all patients are alive<jats:bold>.<\/jats:bold> High\u2010dose <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> is a long\u2010term effective therapy in children and adolescents with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.13453","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T05:45:27Z","timestamp":1429508727000},"page":"398-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Long\u2010term results of high\u2010dose imatinib in children and adolescents with chronic myeloid leukaemia in chronic phase: the Italian experience"],"prefix":"10.1111","volume":"170","author":[{"given":"Fiorina","family":"Giona","sequence":"first","affiliation":[{"name":"Haematology Department of Cellular Biotechnologies and Haematology \u2018Sapienza\u2019 University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Putti","sequence":"additional","affiliation":[{"name":"Haemato\u2010Oncology Unit Department of Women's and Children's Health University of Padua Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Micalizzi","sequence":"additional","affiliation":[{"name":"Clinical Experimental Haematology Unit Gaslini Research Institute of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Menna","sequence":"additional","affiliation":[{"name":"Paediatric Haematology Unit Pausilipon Hospital Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.","family":"Moleti","sequence":"additional","affiliation":[{"name":"Haematology Department of Cellular Biotechnologies and Haematology \u2018Sapienza\u2019 University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Paediatric Unit \u2018F. 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