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The treatment strategies recommended for these two groups differ substantially; however, it is thought to be impossible to predict the underlying causes of <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content> using conventional laboratory tests. Recent studies show that serum levels of soluble interleukin\u20102 receptor (<jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>2R) and ferritin are useful for differentiating some forms of <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content>. The present study reports that combinations of common laboratory parameters, such as the percentage of total lymphocytes within the peripheral blood leucocyte population, serum levels of lactate dehydrogenase and the <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>2R\/ferritin ratio, are useful for identifying patients with familial haemophagocytic lymphohistiocytosis and for differentiating the underlying aetiology of paediatric <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content> during the early course of the disease. These findings suggest that the pathogenesis of <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content> differs greatly in terms of innate and adaptive immunity depending on the aetiology and may provide a new approach to unravelling the complex pathophysiology underlying this syndrome.<\/jats:p>","DOI":"10.1111\/bjh.13461","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T03:18:59Z","timestamp":1430277539000},"page":"532-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Laboratory parameters identify familial haemophagocytic lymphohistiocytosis from other forms of paediatric haemophagocytosis"],"prefix":"10.1111","volume":"170","author":[{"given":"Takahiro","family":"Yasumi","sequence":"first","affiliation":[{"name":"Department of Paediatrics Kyoto University Graduate School of Medicine Kyoto 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