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Information on the performance of the <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> in multi\u2010centre studies is lacking in the literature. To that end, a collaborative multicentre retrospective study was initiated. Comorbidity data from 2523 consecutive recipients of human leucocyte antigen\u2010matched grafts from five different <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> institutions were analysed. Among all patients, <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> scores of 0 vs. 1\u20132 vs. \u22653 were associated with 2\u2013year <jats:styled-content style=\"fixed-case\">NRM<\/jats:styled-content> rates of 14%, 23% and 39% (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00\u00b70001), respectively, and 2\u2013year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) rates of 74%, 61% and 39%, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001). Using regression models, increasing <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> scores were independently associated with increases in hazard ratios for <jats:styled-content style=\"fixed-case\">NRM<\/jats:styled-content> and worse survival within individual institutions. The <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> retained independent capacity for association with outcomes within different age as well as conditioning intensity groups. C\u2010statistic estimates for the prognostic power of the <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">NRM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> were 0\u00b766 and 0\u00b764, respectively. The estimates within each institution were overall similar. The <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> is a valid tool for capturing comorbidities and predicting mortality after haematopoietic cell transplantation across different institutions.<\/jats:p>","DOI":"10.1111\/bjh.13476","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T14:44:53Z","timestamp":1430837093000},"page":"574-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Multi\u2010centre validation of the prognostic value of the haematopoietic cell transplantation\u2010 specific comorbidity index among recipient of allogeneic haematopoietic cell transplantation"],"prefix":"10.1111","volume":"170","author":[{"given":"Mahmoud","family":"ElSawy","sequence":"first","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"National Cancer Institute Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry E.","family":"Storer","sequence":"additional","affiliation":[{"name":"Clinical Statistics Program Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Department of Biostatistics University of Washington School of Public Health Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Pulsipher","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Blood and Marrow Transplantation University of Utah School of Medicine Logan UT USA"},{"name":"Pediatric Blood and Marrow Transplant Program Primary Children's Medical Center Huntsman Cancer Institute Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Maziarz","sequence":"additional","affiliation":[{"name":"Center for Hematologic Malignancies OHSU Knight Cancer Institute Portland OR USA"},{"name":"Division of Hematology and Medical Oncology Oregon Health &amp; Science University School of Medicine Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Population Sciences Center for Cancer Survivorship City of Hope School of Medicine Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Maris","sequence":"additional","affiliation":[{"name":"Colorado Blood Cancer Institute School of Medicine Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Syrjala","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of Washington School of Medicine Seattle Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Martin","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Maloney","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda M.","family":"Sandmaier","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Storb","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed L.","family":"Sorror","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Medical Oncology Department of Medicine University of Washington School of Medicine Seattle WA 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