{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:39:12Z","timestamp":1791247152540,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T00:00:00Z","timestamp":1430784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Sickle cell disease induces specific brain alterations that involve both the macrocirculation and the microcirculation. The main overt neurovascular complications in children are infarctive stroke, transient ischaemic attack and cerebral haemorrhage. Silent cerebral infarction, cognitive dysfunction and recurrent headache are also common. Cerebrovascular disease selectively affects children with the Hb\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    or HbS\u2010\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    genotypes (i.e. sickle cell anaemia). The incidence of stroke peaks between 2 and 5\u00a0years of age (1\u00b702\/100 patient\u2010years) and increases with the severity of the anaemia. Most strokes can be prevented by annual transcranial Doppler screening from 2 to 16\u00a0years of age and providing chronic blood transfusion when this investigation shows elevated blood\u2010flow velocities. The role for hydroxycarbamide in children with abnormal transcranial Doppler findings is under investigation. After a stroke, chronic blood transfusion is very strongly recommended, unless haematopoietic stem cell transplantation can be performed. Routine magnetic resonance imaging shows that more than one\u2010third of children have silent cerebral infarction, which is associated with cognitive impairments. Screening for silent infarcts seems legitimate, since their presence may lead to supportive treatments. The role for more aggressive interventions such as hydroxycarbamide or chronic blood transfusion is debated.\n                  <\/jats:p>","DOI":"10.1111\/bjh.13477","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T10:26:56Z","timestamp":1430821616000},"page":"615-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["How I manage cerebral vasculopathy in children with sickle cell disease"],"prefix":"10.1111","volume":"170","author":[{"given":"Valentine","family":"Brousse","sequence":"first","affiliation":[{"name":"Paediatrics and Sickle\u2010Cell Centre University Hospital Necker\u2010Enfants Malades APHP Paris France"},{"name":"UMR S\u20101134 INSERM Paris France"},{"name":"GR\u2010Ex Laboratory of Excellence Paris France"},{"name":"Paris Descartes University Paris 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