{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:02:06Z","timestamp":1774677726557,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>) is essentially incurable with conventional chemotherapy. The <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> International Prognostic Index (<jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>) is a validated specific prognostic index, but was derived from patients with advanced\u2010stage disease primarily in the pre\u2010rituximab era. We analysed 501 <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> patients (median age, 67\u00a0years; range 22\u201390) treated with rituximab\u2010containing chemotherapy, and evaluated the prognostic factors adjusted by the treatment. Five\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) in the low, intermediate and high <jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content> groups was 74%, 70% and 35%, respectively. Additional to <jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content> risk factors, multivariate analysis revealed that low serum albumin and bone\u2010marrow involvement were also significantly associated with a poor outcome. The revised\u2010<jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content> (R\u2010<jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>) was constructed using six factors, namely age, performance status, white blood cell count, serum lactate dehydrogenase, bone\u2010marrow involvement and serum albumin, which is divided into four prognostic groups. Five\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> in low, low\u2010intermediate (L\u2010I), high\u2010intermediate (H\u2010I) and high R\u2010<jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content> groups was 92%, 75%, 61% and 19%, respectively. Hazard ratio for OS of L\u2010I, H\u2010I and high risk to low risk patients were 5\u00b74, 8\u00b73 and 33\u00b70, respectively. R\u2010<jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>, a new prognostic index with easy application to the general patient population, shows promise for identifying low\u2010 and high\u2010risk <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> patients in the rituximab era.<\/jats:p>","DOI":"10.1111\/bjh.13486","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T02:14:54Z","timestamp":1431051294000},"page":"657-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prognostic model for mantle cell lymphoma in the rituximab era: a nationwide study in Japan"],"prefix":"10.1111","volume":"170","author":[{"given":"Dai","family":"Chihara","sequence":"first","affiliation":[{"name":"Department of Lymphoma and Myeloma MD Anderson Cancer Center Houston TX USA"},{"name":"Division of Epidemiology and Prevention Aichi Cancer Centre Research Institute 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