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However, its benefits must be balanced against its risks, including delayed haemolytic transfusion reactions (\n                    <jats:styled-content style=\"fixed-case\">DHTR<\/jats:styled-content>\n                    ). Not only is the relative rate of alloimmunization higher in patients with\n                    <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                    than in other patient populations, but attendant risks associated with\n                    <jats:styled-content style=\"fixed-case\">DHTR<\/jats:styled-content>\n                    are even greater in\n                    <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                    . Clinicians' awareness of\n                    <jats:styled-content style=\"fixed-case\">DHTR<\/jats:styled-content>\n                    events is poor because symptoms of\n                    <jats:styled-content style=\"fixed-case\">DHTR<\/jats:styled-content>\n                    mimic acute vaso\u2010occlusive pain and immunohaematology findings are often negative. Transfusions delivered in the acute rather than elective setting appear to confer a higher risk of\n                    <jats:styled-content style=\"fixed-case\">DHTR<\/jats:styled-content>\n                    . Management of\n                    <jats:styled-content style=\"fixed-case\">DHTR<\/jats:styled-content>\n                    in\n                    <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                    depends on the clinical severity, ranging from supportive care to immunosuppression, and optimization of erythropoiesis.\n                    <jats:styled-content style=\"fixed-case\">DHTR<\/jats:styled-content>\n                    must be considered in any recently transfused patient presenting with acute sickle cell pain. Meticulous documentation of transfusion and immunohaematology history is key. We anticipate an increase in\n                    <jats:styled-content style=\"fixed-case\">DHTR<\/jats:styled-content>\n                    events in\n                    <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                    patients with the increasing use of red blood cell transfusion therapy.\n                  <\/jats:p>","DOI":"10.1111\/bjh.13494","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T06:38:32Z","timestamp":1431499112000},"page":"745-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["How we treat delayed haemolytic transfusion reactions in patients with sickle cell disease"],"prefix":"10.1111","volume":"170","author":[{"given":"Kate","family":"Gardner","sequence":"first","affiliation":[{"name":"Molecular Haematology Faculty of Life Sciences &amp; Medicine King's College London London UK"},{"name":"Department of 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