{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T20:25:06Z","timestamp":1724444706473},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study aimed to determine the extent to which the prognostic advantage of myelodysplastic syndromes (<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>) with del(5q) is due to the more favourable age and sex distribution of patients in that group when compared to other <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> subtypes. A total of 1912 <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> patients from the Duesseldorf registry with less than 5% blasts in the bone marrow were evaluable and had complete covariates. As endpoints, overall survival and progression to acute myeloid leukaemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>) were considered. Cox models were computed for both outcomes. A multivariate Cox model for survival confirmed higher age and male sex as risk factors. In addition, we found a survival advantage of 9\u00b71\u00a0years for <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> del(5q) patients compared to refractory cytopenia with unilineage dysplasia, while the survival advantage of <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> del(5q) over refractory cytopenia with multilineage dysplasia was 18\u00b76\u00a0years. Considering progression to <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>, we did not find any significant differences between the World Health Organization classification subtypes. Our analyses show that the higher survival probabilities of <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> del(5q) patients are not only due to age and sex, although higher age and male sex were also important risk factors. Interestingly, it seems that the survival advantage of <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> del(5q) decreases over time.<\/jats:p>","DOI":"10.1111\/bjh.13496","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T08:19:14Z","timestamp":1431332354000},"page":"687-693","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["In patients with myelodysplastic syndromes with del(5q), factors other than age and sex contribute to the prognostic advantage, which diminishes over time"],"prefix":"10.1111","volume":"170","author":[{"given":"Michael","family":"Lauseker","sequence":"first","affiliation":[{"name":"Institut f\u00fcr medizinische Informationsverarbeitung, Biometrie und Epidemiologie Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen 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